Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979090015> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1979090015 endingPage "519" @default.
- W1979090015 startingPage "513" @default.
- W1979090015 abstract "During Pseudomonas aeruginosa-induced pneumonia in rodents, the acute infiltrate of neutrophils is followed by accumulation of lymphocytes in the perivascular connective tissue. The roles of the adhesion molecules CD11a/CD18 and intercellular adhesion molecule-1 (ICAM-1) in this accumulation of lymphocytes were investigated. The numbers of lymphocytes in P. aeruginosa-induced pneumonia were compared in animals treated with blocking antibodies to either CD11a, ICAM-1, IgG, or no antibody. In other experiments, the lymphocyte accumulation during P. aeruginosa-induced pneumonia in ICAM-1 mutant mice was compared with that in wild-type mice. In rats, both a murine anti-rat CD11a antibody and nonspecific murine IgG partially inhibited the lymphocyte accumulation by 30 to 40% compared with animals that received no antibodies. In mice, blocking antibodies to either CD11a or ICAM-1 did not decrease the lymphocyte accumulation compared with mice given IgG or no antibody. Further, there was no attenuation of the lymphocyte accumulation induced by P. aeruginosa in the ICAM-1 mutant mice compared with wild-type mice, either in the total number of lymphocytes or the number of CD4+, CD8+, or B cells. We conclude that neither CD11a/CD18 nor ICAM-1 are required for lymphocyte accumulation during P. aeruginosa-induced pneumonia in rodents. The partial inhibition of the lymphocyte accumulation in both the anti-CD11a- and IgG-treated rats may be due to nonspecific effects of foreign proteins on cellular functions." @default.
- W1979090015 created "2016-06-24" @default.
- W1979090015 creator A5026821680 @default.
- W1979090015 creator A5032944167 @default.
- W1979090015 creator A5058826692 @default.
- W1979090015 creator A5063744829 @default.
- W1979090015 creator A5067316065 @default.
- W1979090015 creator A5080219607 @default.
- W1979090015 date "1995-05-01" @default.
- W1979090015 modified "2023-09-27" @default.
- W1979090015 title "Lymphocyte accumulation during Pseudomonas aeruginosa-induced pneumonia in rodents does not require CD11a and intercellular adhesion molecule-1." @default.
- W1979090015 doi "https://doi.org/10.1165/ajrcmb.12.5.7742015" @default.
- W1979090015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7742015" @default.
- W1979090015 hasPublicationYear "1995" @default.
- W1979090015 type Work @default.
- W1979090015 sameAs 1979090015 @default.
- W1979090015 citedByCount "3" @default.
- W1979090015 countsByYear W19790900152020 @default.
- W1979090015 crossrefType "journal-article" @default.
- W1979090015 hasAuthorship W1979090015A5026821680 @default.
- W1979090015 hasAuthorship W1979090015A5032944167 @default.
- W1979090015 hasAuthorship W1979090015A5058826692 @default.
- W1979090015 hasAuthorship W1979090015A5063744829 @default.
- W1979090015 hasAuthorship W1979090015A5067316065 @default.
- W1979090015 hasAuthorship W1979090015A5080219607 @default.
- W1979090015 hasBestOaLocation W19790900152 @default.
- W1979090015 hasConcept C153911025 @default.
- W1979090015 hasConcept C159654299 @default.
- W1979090015 hasConcept C16224149 @default.
- W1979090015 hasConcept C185592680 @default.
- W1979090015 hasConcept C203014093 @default.
- W1979090015 hasConcept C2777637488 @default.
- W1979090015 hasConcept C2777761686 @default.
- W1979090015 hasConcept C2909375385 @default.
- W1979090015 hasConcept C523546767 @default.
- W1979090015 hasConcept C53122370 @default.
- W1979090015 hasConcept C542903549 @default.
- W1979090015 hasConcept C54355233 @default.
- W1979090015 hasConcept C62084212 @default.
- W1979090015 hasConcept C86803240 @default.
- W1979090015 hasConcept C89423630 @default.
- W1979090015 hasConceptScore W1979090015C153911025 @default.
- W1979090015 hasConceptScore W1979090015C159654299 @default.
- W1979090015 hasConceptScore W1979090015C16224149 @default.
- W1979090015 hasConceptScore W1979090015C185592680 @default.
- W1979090015 hasConceptScore W1979090015C203014093 @default.
- W1979090015 hasConceptScore W1979090015C2777637488 @default.
- W1979090015 hasConceptScore W1979090015C2777761686 @default.
- W1979090015 hasConceptScore W1979090015C2909375385 @default.
- W1979090015 hasConceptScore W1979090015C523546767 @default.
- W1979090015 hasConceptScore W1979090015C53122370 @default.
- W1979090015 hasConceptScore W1979090015C542903549 @default.
- W1979090015 hasConceptScore W1979090015C54355233 @default.
- W1979090015 hasConceptScore W1979090015C62084212 @default.
- W1979090015 hasConceptScore W1979090015C86803240 @default.
- W1979090015 hasConceptScore W1979090015C89423630 @default.
- W1979090015 hasIssue "5" @default.
- W1979090015 hasLocation W19790900151 @default.
- W1979090015 hasLocation W19790900152 @default.
- W1979090015 hasLocation W19790900153 @default.
- W1979090015 hasOpenAccess W1979090015 @default.
- W1979090015 hasPrimaryLocation W19790900151 @default.
- W1979090015 hasRelatedWork W1803681061 @default.
- W1979090015 hasRelatedWork W1997357203 @default.
- W1979090015 hasRelatedWork W2022678090 @default.
- W1979090015 hasRelatedWork W2033288474 @default.
- W1979090015 hasRelatedWork W2079438216 @default.
- W1979090015 hasRelatedWork W2110688681 @default.
- W1979090015 hasRelatedWork W2134792352 @default.
- W1979090015 hasRelatedWork W2316239013 @default.
- W1979090015 hasRelatedWork W2375797794 @default.
- W1979090015 hasRelatedWork W2409390451 @default.
- W1979090015 hasVolume "12" @default.
- W1979090015 isParatext "false" @default.
- W1979090015 isRetracted "false" @default.
- W1979090015 magId "1979090015" @default.
- W1979090015 workType "article" @default.