FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979097777> ?p ?o ?g. }

• W1979097777 endingPage "170" @default.
• W1979097777 startingPage "161" @default.
• W1979097777 abstract "Background The aim of this study was to estimate the persistence of the most commonly used first-line combined antiretroviral regimens (cART) in HIV-infected adults in the CoRIS cohort. Methods CoRIS is an open prospective multicentre cohort of HIV-infected adults naive to cART at entry. Patients enrolled between January 2008 and June 2010 were included. The main outcome was treatment persistence, defined as time from cART initiation to first treatment change (TC). Cox models taking into account competing risks to estimate sub-hazard ratios (sHR) were performed. Results Of 1,512 patients, 919 (60.8%) initiated cART with the backbone tenofovir disoproxil fumarate (TDF) plus emtricitabine (FTC) plus efavirenz (EFV), 252 (16.7%) plus lopinavir/ritonavir (LPV/r), 129 (8.5%) plus atazanavir/ritonavir (ATV/r), 110 (7.3%) plus darunavir/ritonavir (DRV/r) and 102 (6.7%) plus nevirapine (NVP). Among 414 patients who switched therapy, reason for switching was available for 393. The most frequent reasons were toxicity (40%), simplification (14%) and treatment failure/resistance (13%). In multivariate analyses, there were significant differences in the risk of TC according to initial cART regimen ( P<0.001). Initiating TDF plus FTC with NVP (sHR 1.94, 95% CI 1.38, 2.72) or LPV/r (sHR 1.89, 95% CI 1.45, 2.47) was associated with higher risk of TC than initiating with TDF plus FTC plus EFV. No differences in TC were found between initiating EFV versus ATV/r (sHR 1.29, 95% CI 0.89, 1.86) or DRV/r (sHR 0.98, 95% CI 0.59, 1.65) with TDF plus FTC as backbone. Conclusions Switching from initial cART regimens is frequent, toxicity being the main reason for it. The significantly greater persistence of some combinations may be useful for making decisions when initiating cART." @default.
• W1979097777 created "2016-06-24" @default.
• W1979097777 creator A5002092893 @default.
• W1979097777 creator A5007016487 @default.
• W1979097777 creator A5009215091 @default.
• W1979097777 creator A5016071972 @default.
• W1979097777 creator A5025940626 @default.
• W1979097777 creator A5035652611 @default.
• W1979097777 creator A5041849450 @default.
• W1979097777 creator A5043675426 @default.
• W1979097777 creator A5064279253 @default.
• W1979097777 creator A5064873706 @default.
• W1979097777 date "2012-02-01" @default.
• W1979097777 modified "2023-10-13" @default.
• W1979097777 title "Persistence of Novel First-Line Antiretroviral Regimes in a Cohort of HIV-Positive Subjects, Coris 2008–2010" @default.
• W1979097777 cites W1973860844 @default.
• W1979097777 cites W1976107361 @default.
• W1979097777 cites W1978037518 @default.
• W1979097777 cites W1985646480 @default.
• W1979097777 cites W1986499492 @default.
• W1979097777 cites W2006465209 @default.
• W1979097777 cites W2026372996 @default.
• W1979097777 cites W2028047356 @default.
• W1979097777 cites W2029473103 @default.
• W1979097777 cites W2032623485 @default.
• W1979097777 cites W2038981426 @default.
• W1979097777 cites W2041055738 @default.
• W1979097777 cites W2057847137 @default.
• W1979097777 cites W2063329141 @default.
• W1979097777 cites W2066985929 @default.
• W1979097777 cites W2074919119 @default.
• W1979097777 cites W2081555959 @default.
• W1979097777 cites W2091582739 @default.
• W1979097777 cites W2092195709 @default.
• W1979097777 cites W2099502161 @default.
• W1979097777 cites W2100388346 @default.
• W1979097777 cites W2108513094 @default.
• W1979097777 cites W2110937228 @default.
• W1979097777 cites W2114294800 @default.
• W1979097777 cites W2132102209 @default.
• W1979097777 cites W2136381344 @default.
• W1979097777 cites W2139062201 @default.
• W1979097777 cites W2154746519 @default.
• W1979097777 cites W2156085525 @default.
• W1979097777 cites W2318289184 @default.
• W1979097777 cites W2327498456 @default.
• W1979097777 cites W4240153861 @default.
• W1979097777 doi "https://doi.org/10.3851/imp2287" @default.
• W1979097777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22997147" @default.
• W1979097777 hasPublicationYear "2012" @default.
• W1979097777 type Work @default.
• W1979097777 sameAs 1979097777 @default.
• W1979097777 citedByCount "16" @default.
• W1979097777 countsByYear W19790977772013 @default.
• W1979097777 countsByYear W19790977772014 @default.
• W1979097777 countsByYear W19790977772015 @default.
• W1979097777 countsByYear W19790977772016 @default.
• W1979097777 countsByYear W19790977772017 @default.
• W1979097777 countsByYear W19790977772018 @default.
• W1979097777 countsByYear W19790977772020 @default.
• W1979097777 countsByYear W19790977772022 @default.
• W1979097777 crossrefType "journal-article" @default.
• W1979097777 hasAuthorship W1979097777A5002092893 @default.
• W1979097777 hasAuthorship W1979097777A5007016487 @default.
• W1979097777 hasAuthorship W1979097777A5009215091 @default.
• W1979097777 hasAuthorship W1979097777A5016071972 @default.
• W1979097777 hasAuthorship W1979097777A5025940626 @default.
• W1979097777 hasAuthorship W1979097777A5035652611 @default.
• W1979097777 hasAuthorship W1979097777A5041849450 @default.
• W1979097777 hasAuthorship W1979097777A5043675426 @default.
• W1979097777 hasAuthorship W1979097777A5064279253 @default.
• W1979097777 hasAuthorship W1979097777A5064873706 @default.
• W1979097777 hasBestOaLocation W19790977771 @default.
• W1979097777 hasConcept C126322002 @default.
• W1979097777 hasConcept C127413603 @default.
• W1979097777 hasConcept C142462285 @default.
• W1979097777 hasConcept C159047783 @default.
• W1979097777 hasConcept C188816634 @default.
• W1979097777 hasConcept C207103383 @default.
• W1979097777 hasConcept C2777182164 @default.
• W1979097777 hasConcept C2777275308 @default.
• W1979097777 hasConcept C2778414717 @default.
• W1979097777 hasConcept C2779130552 @default.
• W1979097777 hasConcept C2779182219 @default.
• W1979097777 hasConcept C2779298103 @default.
• W1979097777 hasConcept C2779778239 @default.
• W1979097777 hasConcept C2781392899 @default.
• W1979097777 hasConcept C2781413609 @default.
• W1979097777 hasConcept C2781432083 @default.
• W1979097777 hasConcept C2993143319 @default.
• W1979097777 hasConcept C3013748606 @default.
• W1979097777 hasConcept C44249647 @default.
• W1979097777 hasConcept C50382708 @default.
• W1979097777 hasConcept C71924100 @default.
• W1979097777 hasConcept C72563966 @default.
• W1979097777 hasConcept C78519656 @default.
• W1979097777 hasConceptScore W1979097777C126322002 @default.
• W1979097777 hasConceptScore W1979097777C127413603 @default.

• next