FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979100629> ?p ?o ?g. }

• W1979100629 endingPage "85" @default.
• W1979100629 startingPage "75" @default.
• W1979100629 abstract "1. To investigate whether the cystic fibrosis transmembrane conductance regulator (CFTR) interacts with volume regulated anion channels (VRACs), we measured the volume-activated chloride current (ICl,swell) using the whole-cell patch-clamp technique in calf pulmonary artery endothelial (CPAE) cells and in COS cells transiently transfected with wild-type (WT) CFTR and the deletion mutant DeltaF508 CFTR. 2. ICl,swell was significantly reduced in CPAE cells expressing WT CFTR to 66.5 +/- 8.8 % (n = 13; mean +/- s. e.m.) of the control value (n = 11). This reduction was independent of activation of the CFTR channel. 3. Expression of DeltaF508 CFTR resulted in two groups of CPAE cells. In the first group IBMX and forskolin could activate a Cl- current. In these cells ICl,swell was reduced to 52.7 +/- 18.8 % (n = 5) of the control value (n = 21). In the second group IBMX and forskolin could not activate a current. The amplitude of ICl,swell in these cells was not significantly different from the control value (112.4 +/- 13.7 %, n = 11; 21 control cells). 4. Using the same method we showed that expression of WT CFTR in COS cells reduced ICl,swell to 62.1 +/- 11.9 % (n = 14) of the control value (n = 12) without any changes in the kinetics of the current. Non-stationary noise analysis suggested that there is no significant difference in the single channel conductance of VRAC between CFTR expressing and non-expressing COS cells. 5. We conclude that expression of WT CFTR down-regulates ICl, swell in CPAE and COS cells, suggesting an interaction between CFTR and VRAC independent of activation of CFTR." @default.
• W1979100629 created "2016-06-24" @default.
• W1979100629 creator A5016643155 @default.
• W1979100629 creator A5017782999 @default.
• W1979100629 creator A5021952303 @default.
• W1979100629 creator A5044371953 @default.
• W1979100629 creator A5056938065 @default.
• W1979100629 creator A5058777914 @default.
• W1979100629 creator A5071455949 @default.
• W1979100629 creator A5081873679 @default.
• W1979100629 creator A5087089940 @default.
• W1979100629 date "1999-02-01" @default.
• W1979100629 modified "2023-09-30" @default.
• W1979100629 title "Inhibition of volume‐regulated anion channels by expression of the cystic fibrosis transmembrane conductance regulator" @default.
• W1979100629 cites W1484411973 @default.
• W1979100629 cites W165204032 @default.
• W1979100629 cites W1963761882 @default.
• W1979100629 cites W1990687915 @default.
• W1979100629 cites W1997511216 @default.
• W1979100629 cites W1999390563 @default.
• W1979100629 cites W2009667219 @default.
• W1979100629 cites W2010226740 @default.
• W1979100629 cites W2010623159 @default.
• W1979100629 cites W2015426350 @default.
• W1979100629 cites W2019099644 @default.
• W1979100629 cites W2030374599 @default.
• W1979100629 cites W2044594872 @default.
• W1979100629 cites W2045547109 @default.
• W1979100629 cites W2054895013 @default.
• W1979100629 cites W2061905631 @default.
• W1979100629 cites W2062364311 @default.
• W1979100629 cites W2065808695 @default.
• W1979100629 cites W2068233575 @default.
• W1979100629 cites W2068503503 @default.
• W1979100629 cites W2070433585 @default.
• W1979100629 cites W2075783292 @default.
• W1979100629 cites W2077222397 @default.
• W1979100629 cites W2094173061 @default.
• W1979100629 cites W2095852063 @default.
• W1979100629 cites W2104316598 @default.
• W1979100629 cites W2123811084 @default.
• W1979100629 cites W2126458759 @default.
• W1979100629 cites W2128734935 @default.
• W1979100629 cites W2131458670 @default.
• W1979100629 cites W2132471653 @default.
• W1979100629 cites W2136598957 @default.
• W1979100629 cites W2141989775 @default.
• W1979100629 cites W2150719255 @default.
• W1979100629 cites W2172978832 @default.
• W1979100629 cites W2277417740 @default.
• W1979100629 cites W2290010678 @default.
• W1979100629 cites W2316634253 @default.
• W1979100629 cites W2342208005 @default.
• W1979100629 cites W2403290518 @default.
• W1979100629 cites W2429848542 @default.
• W1979100629 doi "https://doi.org/10.1111/j.1469-7793.1999.075ad.x" @default.
• W1979100629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2269134" @default.
• W1979100629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9925879" @default.
• W1979100629 hasPublicationYear "1999" @default.
• W1979100629 type Work @default.
• W1979100629 sameAs 1979100629 @default.
• W1979100629 citedByCount "56" @default.
• W1979100629 countsByYear W19791006292012 @default.
• W1979100629 countsByYear W19791006292013 @default.
• W1979100629 countsByYear W19791006292014 @default.
• W1979100629 countsByYear W19791006292015 @default.
• W1979100629 countsByYear W19791006292017 @default.
• W1979100629 countsByYear W19791006292018 @default.
• W1979100629 countsByYear W19791006292019 @default.
• W1979100629 countsByYear W19791006292021 @default.
• W1979100629 countsByYear W19791006292022 @default.
• W1979100629 crossrefType "journal-article" @default.
• W1979100629 hasAuthorship W1979100629A5016643155 @default.
• W1979100629 hasAuthorship W1979100629A5017782999 @default.
• W1979100629 hasAuthorship W1979100629A5021952303 @default.
• W1979100629 hasAuthorship W1979100629A5044371953 @default.
• W1979100629 hasAuthorship W1979100629A5056938065 @default.
• W1979100629 hasAuthorship W1979100629A5058777914 @default.
• W1979100629 hasAuthorship W1979100629A5071455949 @default.
• W1979100629 hasAuthorship W1979100629A5081873679 @default.
• W1979100629 hasAuthorship W1979100629A5087089940 @default.
• W1979100629 hasBestOaLocation W19791006292 @default.
• W1979100629 hasConcept C104317684 @default.
• W1979100629 hasConcept C12554922 @default.
• W1979100629 hasConcept C126322002 @default.
• W1979100629 hasConcept C134018914 @default.
• W1979100629 hasConcept C145822097 @default.
• W1979100629 hasConcept C147944092 @default.
• W1979100629 hasConcept C153911025 @default.
• W1979100629 hasConcept C170493617 @default.
• W1979100629 hasConcept C185592680 @default.
• W1979100629 hasConcept C202751555 @default.
• W1979100629 hasConcept C2778428886 @default.
• W1979100629 hasConcept C2779276759 @default.
• W1979100629 hasConcept C2781298581 @default.
• W1979100629 hasConcept C55493867 @default.
• W1979100629 hasConcept C71924100 @default.
• W1979100629 hasConcept C86803240 @default.

• next