FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979102578> ?p ?o ?g. }

• W1979102578 endingPage "e77048" @default.
• W1979102578 startingPage "e77048" @default.
• W1979102578 abstract "Background The protective effects of granulocyte colony-stimulating factor (G-CSF) have been demonstrated in a variety of renal disease models. However, the influence of G-CSF on diabetic nephropathy (DN) remains to be examined. In this study, we investigated the effect of G-CSF on DN and its possible mechanisms in a rat model. Methods Otsuka Long-Evans Tokushima Fatty (OLETF) rats with early DN were administered G-CSF or saline intraperitoneally. Urine albumin creatinine ratio (UACR), creatinine clearance, mesangial matrix expansion, glomerular basement membrane (GBM) thickness, and podocyte foot process width (FPW) were measured. The levels of interleukin (IL)-1β, transforming growth factor (TGF)-β1, and type IV collagen genes expression in kidney tissue were also evaluated. To elucidate the mechanisms underlying G-CSF effects, we also assessed the expression of G-CSF receptor (G-CSFR) in glomeruli as well as mobilization of bone marrow (BM) cells to glomeruli using sex-mismatched BM transplantation. Results After four weeks of treatment, UACR was lower in the G-CSF treatment group than in the saline group (p<0.05), as were mesangial matrix expansion, GBM thickness, and FPW (p<0.05). In addition, the expression of TGF-β1 and type IV collagen and IL-1β levels was lower in the G-CSF treatment group (p<0.05). G-CSFR was not present in glomerular cells, and G-CSF treatment increased the number of BM-derived cells in glomeruli (p<0.05). Conclusions G-CSF can prevent the progression of DN in OLETF rats and its effects may be due to mobilization of BM cells rather than being a direct effect." @default.
• W1979102578 created "2016-06-24" @default.
• W1979102578 creator A5021584969 @default.
• W1979102578 creator A5022870510 @default.
• W1979102578 creator A5031783701 @default.
• W1979102578 creator A5045493042 @default.
• W1979102578 creator A5049235418 @default.
• W1979102578 creator A5049569161 @default.
• W1979102578 creator A5058505853 @default.
• W1979102578 creator A5065768200 @default.
• W1979102578 date "2013-10-22" @default.
• W1979102578 modified "2023-09-29" @default.
• W1979102578 title "G-CSF Prevents Progression of Diabetic Nephropathy in Rat" @default.
• W1979102578 cites W1963864987 @default.
• W1979102578 cites W1975915536 @default.
• W1979102578 cites W1977395180 @default.
• W1979102578 cites W1986454739 @default.
• W1979102578 cites W1987075250 @default.
• W1979102578 cites W1995553759 @default.
• W1979102578 cites W2007378287 @default.
• W1979102578 cites W2017416417 @default.
• W1979102578 cites W2017905408 @default.
• W1979102578 cites W2018793121 @default.
• W1979102578 cites W2022553426 @default.
• W1979102578 cites W2033503356 @default.
• W1979102578 cites W2040961193 @default.
• W1979102578 cites W2041544514 @default.
• W1979102578 cites W2064185517 @default.
• W1979102578 cites W2078133891 @default.
• W1979102578 cites W2083712121 @default.
• W1979102578 cites W2086680310 @default.
• W1979102578 cites W2089300900 @default.
• W1979102578 cites W2096556016 @default.
• W1979102578 cites W2099161225 @default.
• W1979102578 cites W2100238516 @default.
• W1979102578 cites W2101051256 @default.
• W1979102578 cites W2104082850 @default.
• W1979102578 cites W2105151699 @default.
• W1979102578 cites W2108192985 @default.
• W1979102578 cites W2112174413 @default.
• W1979102578 cites W2114412986 @default.
• W1979102578 cites W2114805956 @default.
• W1979102578 cites W2122380860 @default.
• W1979102578 cites W2128877622 @default.
• W1979102578 cites W2136530061 @default.
• W1979102578 cites W2142772396 @default.
• W1979102578 cites W2151918150 @default.
• W1979102578 cites W2160588155 @default.
• W1979102578 cites W2257979511 @default.
• W1979102578 cites W2338649218 @default.
• W1979102578 cites W38571946 @default.
• W1979102578 cites W4230399767 @default.
• W1979102578 cites W4254227099 @default.
• W1979102578 doi "https://doi.org/10.1371/journal.pone.0077048" @default.
• W1979102578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3805566" @default.
• W1979102578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24167558" @default.
• W1979102578 hasPublicationYear "2013" @default.
• W1979102578 type Work @default.
• W1979102578 sameAs 1979102578 @default.
• W1979102578 citedByCount "18" @default.
• W1979102578 countsByYear W19791025782014 @default.
• W1979102578 countsByYear W19791025782015 @default.
• W1979102578 countsByYear W19791025782016 @default.
• W1979102578 countsByYear W19791025782018 @default.
• W1979102578 countsByYear W19791025782019 @default.
• W1979102578 countsByYear W19791025782020 @default.
• W1979102578 countsByYear W19791025782021 @default.
• W1979102578 countsByYear W19791025782022 @default.
• W1979102578 crossrefType "journal-article" @default.
• W1979102578 hasAuthorship W1979102578A5021584969 @default.
• W1979102578 hasAuthorship W1979102578A5022870510 @default.
• W1979102578 hasAuthorship W1979102578A5031783701 @default.
• W1979102578 hasAuthorship W1979102578A5045493042 @default.
• W1979102578 hasAuthorship W1979102578A5049235418 @default.
• W1979102578 hasAuthorship W1979102578A5049569161 @default.
• W1979102578 hasAuthorship W1979102578A5058505853 @default.
• W1979102578 hasAuthorship W1979102578A5065768200 @default.
• W1979102578 hasBestOaLocation W19791025781 @default.
• W1979102578 hasConcept C118131993 @default.
• W1979102578 hasConcept C126322002 @default.
• W1979102578 hasConcept C134018914 @default.
• W1979102578 hasConcept C170493617 @default.
• W1979102578 hasConcept C2775946357 @default.
• W1979102578 hasConcept C2775960820 @default.
• W1979102578 hasConcept C2776115139 @default.
• W1979102578 hasConcept C2777146197 @default.
• W1979102578 hasConcept C2777390665 @default.
• W1979102578 hasConcept C2777397205 @default.
• W1979102578 hasConcept C2779561371 @default.
• W1979102578 hasConcept C2779922275 @default.
• W1979102578 hasConcept C2780091579 @default.
• W1979102578 hasConcept C2780306776 @default.
• W1979102578 hasConcept C2780368995 @default.
• W1979102578 hasConcept C2780688133 @default.
• W1979102578 hasConcept C71924100 @default.
• W1979102578 hasConceptScore W1979102578C118131993 @default.
• W1979102578 hasConceptScore W1979102578C126322002 @default.
• W1979102578 hasConceptScore W1979102578C134018914 @default.

• next