FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979111762> ?p ?o ?g. }

• W1979111762 endingPage "39" @default.
• W1979111762 startingPage "35" @default.
• W1979111762 abstract "A proportion of healthy siblings of multiple sclerosis (MS) patients have an oligoclonal immunological reaction in their cerebrospinal fluid (CSF) termed the “MS oligoclonal trait”. The CSF levels of the major myelin glycosphingolipid sulfatide and serum antibodies against the glycosphingolipids sulfatide and galactosylceramide were recently reported to be increased in MS patients. We studied the levels of these substances in pairs of 46 patients and their 46 healthy siblings and 50 unrelated healthy blood donors (HBD). The sulfatide concentration in CSF was assayed by thin layer chromatography and immunostaining, and the concentration of galactosylceramide by densitometry after thin layer chromatography. Anti-glycosphingolipid antibody levels were assayed by ELISA. In the healthy siblings, the CSF sulfatide concentrations were markedly increased (p<0.001, age adjusted p=0.025), and the serum IgM anti-GalCer antibodies were increased in healthy siblings compared with HBD (p=0.02). The increased sulfatide or antibody levels did not co-segregate with the “MS oligoclonal trait” or the HLA-DR15 phenotype. In conclusion, a proportion of healthy siblings of MS patients have increased CSF sulfatide and anti-glycosphingolipid antibody levels, which may, analogous to the “MS oligoclonal trait”, constitute an “MS glycosphingolipid endophenotype”. Endophenotypes could potentially simplify the genetics of complex disorders." @default.
• W1979111762 created "2016-06-24" @default.
• W1979111762 creator A5018810546 @default.
• W1979111762 creator A5052167611 @default.
• W1979111762 creator A5054250152 @default.
• W1979111762 creator A5068421341 @default.
• W1979111762 creator A5091296158 @default.
• W1979111762 date "2013-03-01" @default.
• W1979111762 modified "2023-09-25" @default.
• W1979111762 title "Increased CSF sulfatide levels and serum glycosphingolipid antibody levels in healthy siblings of multiple sclerosis patients" @default.
• W1979111762 cites W1597858230 @default.
• W1979111762 cites W1654544193 @default.
• W1979111762 cites W1968279358 @default.
• W1979111762 cites W1972085567 @default.
• W1979111762 cites W1980627887 @default.
• W1979111762 cites W1984377214 @default.
• W1979111762 cites W1990425546 @default.
• W1979111762 cites W1992322039 @default.
• W1979111762 cites W2000164166 @default.
• W1979111762 cites W2004416668 @default.
• W1979111762 cites W2006601180 @default.
• W1979111762 cites W2016644380 @default.
• W1979111762 cites W2019388681 @default.
• W1979111762 cites W2020040819 @default.
• W1979111762 cites W2022139349 @default.
• W1979111762 cites W2024192918 @default.
• W1979111762 cites W2031073334 @default.
• W1979111762 cites W2038237582 @default.
• W1979111762 cites W2059432078 @default.
• W1979111762 cites W2059648100 @default.
• W1979111762 cites W2069753488 @default.
• W1979111762 cites W2083875480 @default.
• W1979111762 cites W2090225977 @default.
• W1979111762 cites W2094682437 @default.
• W1979111762 cites W2102945024 @default.
• W1979111762 cites W2127098303 @default.
• W1979111762 cites W2144697640 @default.
• W1979111762 cites W2145737978 @default.
• W1979111762 cites W2146738944 @default.
• W1979111762 cites W2149134458 @default.
• W1979111762 cites W2152074235 @default.
• W1979111762 cites W2155034071 @default.
• W1979111762 cites W2171638494 @default.
• W1979111762 cites W2315568683 @default.
• W1979111762 cites W4236254399 @default.
• W1979111762 cites W7805967 @default.
• W1979111762 doi "https://doi.org/10.1016/j.jns.2013.01.007" @default.
• W1979111762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23385003" @default.
• W1979111762 hasPublicationYear "2013" @default.
• W1979111762 type Work @default.
• W1979111762 sameAs 1979111762 @default.
• W1979111762 citedByCount "16" @default.
• W1979111762 countsByYear W19791117622013 @default.
• W1979111762 countsByYear W19791117622014 @default.
• W1979111762 countsByYear W19791117622015 @default.
• W1979111762 countsByYear W19791117622016 @default.
• W1979111762 countsByYear W19791117622017 @default.
• W1979111762 countsByYear W19791117622018 @default.
• W1979111762 countsByYear W19791117622020 @default.
• W1979111762 countsByYear W19791117622021 @default.
• W1979111762 countsByYear W19791117622022 @default.
• W1979111762 countsByYear W19791117622023 @default.
• W1979111762 crossrefType "journal-article" @default.
• W1979111762 hasAuthorship W1979111762A5018810546 @default.
• W1979111762 hasAuthorship W1979111762A5052167611 @default.
• W1979111762 hasAuthorship W1979111762A5054250152 @default.
• W1979111762 hasAuthorship W1979111762A5068421341 @default.
• W1979111762 hasAuthorship W1979111762A5091296158 @default.
• W1979111762 hasConcept C118552586 @default.
• W1979111762 hasConcept C126322002 @default.
• W1979111762 hasConcept C134018914 @default.
• W1979111762 hasConcept C159654299 @default.
• W1979111762 hasConcept C169900460 @default.
• W1979111762 hasConcept C185592680 @default.
• W1979111762 hasConcept C187869287 @default.
• W1979111762 hasConcept C203014093 @default.
• W1979111762 hasConcept C204232928 @default.
• W1979111762 hasConcept C2776931407 @default.
• W1979111762 hasConcept C2779651940 @default.
• W1979111762 hasConcept C2780640218 @default.
• W1979111762 hasConcept C4224716 @default.
• W1979111762 hasConcept C55493867 @default.
• W1979111762 hasConcept C71924100 @default.
• W1979111762 hasConceptScore W1979111762C118552586 @default.
• W1979111762 hasConceptScore W1979111762C126322002 @default.
• W1979111762 hasConceptScore W1979111762C134018914 @default.
• W1979111762 hasConceptScore W1979111762C159654299 @default.
• W1979111762 hasConceptScore W1979111762C169900460 @default.
• W1979111762 hasConceptScore W1979111762C185592680 @default.
• W1979111762 hasConceptScore W1979111762C187869287 @default.
• W1979111762 hasConceptScore W1979111762C203014093 @default.
• W1979111762 hasConceptScore W1979111762C204232928 @default.
• W1979111762 hasConceptScore W1979111762C2776931407 @default.
• W1979111762 hasConceptScore W1979111762C2779651940 @default.
• W1979111762 hasConceptScore W1979111762C2780640218 @default.
• W1979111762 hasConceptScore W1979111762C4224716 @default.
• W1979111762 hasConceptScore W1979111762C55493867 @default.
• W1979111762 hasConceptScore W1979111762C71924100 @default.

• next