FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979116835> ?p ?o ?g. }

• W1979116835 endingPage "488" @default.
• W1979116835 startingPage "477" @default.
• W1979116835 abstract "A new panel of mAbs was prepared to a stromal cell line known to support lymphocytes in Whitlock-Witte type long-term bone marrow cultures. These antibodies were then screened with a cell adhesion assay and four were selected that inhibited the binding of B lineage cells to stromal cell monolayers. Immunofluorescent and biochemical analyses revealed that these new antibodies detected epitopes of the previously described Pgp-1/CD44 antigen complex. Addition of Pgp-1/CD44 antibodies to Dexter-type long-term bone marrow cultures completely prevented emergence of myeloid cells and they also blocked lymphocyte growth in Whitlock-Witte type cultures. mAbs MEL-14, LFA-1, and CD45R did not inhibit under the same conditions and there was no apparent relationship to Ig isotype. Adherent layers in treated cultures were not unusual in terms of morphology and the antibodies did not affect factor-dependent replication of lymphoid or myeloid progenitor cells. Therefore, the mechanism of inhibition may not involve direct toxicity to precursors or microenvironmental elements. Previous studies in humans and mice have implicated Pgp-1/CD44-related glycoproteins in the migration of peripheral lymphoid cells, as well as interactions of cells with the extracellular matrix. These findings suggest that they may also be critical for formation of lymphoid and myeloid cells within bone marrow." @default.
• W1979116835 created "2016-06-24" @default.
• W1979116835 creator A5015803537 @default.
• W1979116835 creator A5016982418 @default.
• W1979116835 creator A5048705945 @default.
• W1979116835 creator A5076624164 @default.
• W1979116835 creator A5087021732 @default.
• W1979116835 creator A5089501781 @default.
• W1979116835 date "1990-02-01" @default.
• W1979116835 modified "2023-10-16" @default.
• W1979116835 title "Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures." @default.
• W1979116835 cites W1487766219 @default.
• W1979116835 cites W1517355410 @default.
• W1979116835 cites W1534222607 @default.
• W1979116835 cites W1538228837 @default.
• W1979116835 cites W1544936755 @default.
• W1979116835 cites W1571114305 @default.
• W1979116835 cites W1664246182 @default.
• W1979116835 cites W1934486814 @default.
• W1979116835 cites W1944598762 @default.
• W1979116835 cites W1965357348 @default.
• W1979116835 cites W1976747503 @default.
• W1979116835 cites W1996787107 @default.
• W1979116835 cites W2001035036 @default.
• W1979116835 cites W2002563977 @default.
• W1979116835 cites W2005915396 @default.
• W1979116835 cites W2027839043 @default.
• W1979116835 cites W2040544223 @default.
• W1979116835 cites W2041887961 @default.
• W1979116835 cites W2047799290 @default.
• W1979116835 cites W2061314975 @default.
• W1979116835 cites W2082808480 @default.
• W1979116835 cites W2086793358 @default.
• W1979116835 cites W2098136836 @default.
• W1979116835 cites W2098758154 @default.
• W1979116835 cites W2129845257 @default.
• W1979116835 cites W2138182020 @default.
• W1979116835 cites W2145845008 @default.
• W1979116835 cites W2160985360 @default.
• W1979116835 cites W2164937884 @default.
• W1979116835 cites W2417760639 @default.
• W1979116835 cites W315922340 @default.
• W1979116835 cites W331893476 @default.
• W1979116835 cites W4243487702 @default.
• W1979116835 doi "https://doi.org/10.1084/jem.171.2.477" @default.
• W1979116835 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2187725" @default.
• W1979116835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2406365" @default.
• W1979116835 hasPublicationYear "1990" @default.
• W1979116835 type Work @default.
• W1979116835 sameAs 1979116835 @default.
• W1979116835 citedByCount "561" @default.
• W1979116835 countsByYear W19791168352012 @default.
• W1979116835 countsByYear W19791168352013 @default.
• W1979116835 countsByYear W19791168352014 @default.
• W1979116835 countsByYear W19791168352015 @default.
• W1979116835 countsByYear W19791168352016 @default.
• W1979116835 countsByYear W19791168352018 @default.
• W1979116835 countsByYear W19791168352019 @default.
• W1979116835 countsByYear W19791168352020 @default.
• W1979116835 countsByYear W19791168352023 @default.
• W1979116835 crossrefType "journal-article" @default.
• W1979116835 hasAuthorship W1979116835A5015803537 @default.
• W1979116835 hasAuthorship W1979116835A5016982418 @default.
• W1979116835 hasAuthorship W1979116835A5048705945 @default.
• W1979116835 hasAuthorship W1979116835A5076624164 @default.
• W1979116835 hasAuthorship W1979116835A5087021732 @default.
• W1979116835 hasAuthorship W1979116835A5089501781 @default.
• W1979116835 hasBestOaLocation W19791168351 @default.
• W1979116835 hasConcept C109159458 @default.
• W1979116835 hasConcept C147483822 @default.
• W1979116835 hasConcept C1491633281 @default.
• W1979116835 hasConcept C153911025 @default.
• W1979116835 hasConcept C159654299 @default.
• W1979116835 hasConcept C16930146 @default.
• W1979116835 hasConcept C195616568 @default.
• W1979116835 hasConcept C203014093 @default.
• W1979116835 hasConcept C2777761686 @default.
• W1979116835 hasConcept C2779282312 @default.
• W1979116835 hasConcept C2780007613 @default.
• W1979116835 hasConcept C2780932548 @default.
• W1979116835 hasConcept C28328180 @default.
• W1979116835 hasConcept C502942594 @default.
• W1979116835 hasConcept C542903549 @default.
• W1979116835 hasConcept C55493867 @default.
• W1979116835 hasConcept C86803240 @default.
• W1979116835 hasConcept C95444343 @default.
• W1979116835 hasConceptScore W1979116835C109159458 @default.
• W1979116835 hasConceptScore W1979116835C147483822 @default.
• W1979116835 hasConceptScore W1979116835C1491633281 @default.
• W1979116835 hasConceptScore W1979116835C153911025 @default.
• W1979116835 hasConceptScore W1979116835C159654299 @default.
• W1979116835 hasConceptScore W1979116835C16930146 @default.
• W1979116835 hasConceptScore W1979116835C195616568 @default.
• W1979116835 hasConceptScore W1979116835C203014093 @default.
• W1979116835 hasConceptScore W1979116835C2777761686 @default.
• W1979116835 hasConceptScore W1979116835C2779282312 @default.
• W1979116835 hasConceptScore W1979116835C2780007613 @default.
• W1979116835 hasConceptScore W1979116835C2780932548 @default.

• next