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- W1979117446 abstract "Mutations at the period (per) locus (1:1.3; 3B1-2) in Drosophila melanogaster lengthen (perL), shorten (pers), or abolish (per0) overt circadian rhythmicity. Deuterium oxide lengthens the free-running circadian period. We tested the effects of deuterium on three mutants of the per gene (pers, perL, and per0) and wild-type Drosophila melanogaster (per+) to assess interactions. With increasing concentrations of deuterium, the free-running circadian period of locomotor activity rhythms increased. The dose-response was linear in all genotypes tested. With increasing dosages of deuterium, circadian rhythms became weaker as evidenced by the signal-to-noise ratio (SNR). Genotype and deuterium changed circadian period length independently and additively, showing no interaction. SNRs for all genotypes converged on a low level as deuterium concentration increased. Deuterium increased life span, except at high concentrations (40 and 50%)." @default.
- W1979117446 created "2016-06-24" @default.
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- W1979117446 date "1992-01-01" @default.
- W1979117446 modified "2023-10-16" @default.
- W1979117446 title "A Circadian Clock of Drosophila: Effects of Deuterium Oxide and Mutations at the period Locus" @default.
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- W1979117446 doi "https://doi.org/10.3109/07420529209064534" @default.
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