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• W1979129085 abstract "Human colorectal carcinoma tissue sampled from 37 patients, routinely graded into Dukes' stages A, B and C and histologically examined for the level of differentiation, were analyzed for the presence of point mutations in the K-ras oncogene. Seventeen cases out of the 37 analyzed were found to have a mutation in either the 12th or the 13th codon of the K-ras gene, giving an overall frequency of mutation of 46%. The incidence of mutations in Dukes' stages A, B and C was 33, 46 and 58% respectively. Although the frequency of mutation appears to be similar to that reported for the USA population, the spectrum of point mutations in codons 12 and 13 of the K-ras gene in the Yugoslav population appears to differ significantly. G-to-T transversions make up 77% of all mutations present, with the distribution as follows: 18% at the first base and 59% at the second base of codons 12 and 13. G-to-A transitions at the second base is the only other mutation identified, occurring mainly in codon 13 in colorectal tumors of all 3 stages." @default.
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• W1979129085 date "1993-05-08" @default.
• W1979129085 modified "2023-09-25" @default.
• W1979129085 title "Prevalence of G-TO-T transversions among K-ras oncogene mutations in human colorectal tumors in Yugoslavia" @default.
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• W1979129085 doi "https://doi.org/10.1002/ijc.2910540215" @default.
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