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- W1979147695 abstract "Ross River (RR) virus is an alphavirus endemic to Australia and New Guinea and is the aetiological agent of epidemic polyarthritis or RR virus disease. Here we provide evidence that RR virus uses the collagen-binding α1β1 integrin as a cellular receptor. Infection could be inhibited by collagen IV and antibodies specific for the β1 and α1 integrin proteins, and fibroblasts from α1-integrin−/− mice were less efficiently infected than wild-type fibroblasts. Soluble α1β1 integrin bound immobilized RR virus, and peptides representing the α1β1 integrin binding-site on collagen IV inhibited virus binding to cells. We speculate that two highly conserved regions within the cell-receptor binding domain of E2 mimic collagen and provide access to cellular collagen-binding receptors." @default.
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- W1979147695 date "2005-06-01" @default.
- W1979147695 modified "2023-09-26" @default.
- W1979147695 title "An arthritogenic alphavirus uses the α1β1 integrin collagen receptor" @default.
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- W1979147695 doi "https://doi.org/10.1016/j.virol.2005.03.015" @default.
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