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- W1979157547 abstract "A novel lotus plumule polysaccharide (LPPS) was administered to non-obese diabetic (NOD) mice for 15weeks to evaluate the protective effects of LPPS on type 1 diabetes. After the 15-week feeding experiment, tumour necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10 expressions in the spleen, liver and kidney of the experimental mice were measured using enzyme-linked immunosorbent assay or real-time quantitative polymerase chain reaction assay. The results showed that LPPS significantly (p<0.05) decreased the absolute weights of the enlarged spleens in the NOD mice in a dose-dependent manner, inhibited pro-inflammatory TNF-α and IL-6 cytokine production and decreased the secretion ratio of IL-6/IL-10 in splenocyte cultures. LPPS markedly decreased the relative expression of pro-/anti-inflammatory cytokine genes (TNF-α/IL-10 and IL-6/IL-10) in the livers of NOD mice. Our results suggest that LPPS protected the spleen and liver from spontaneous inflammation in NOD mice by modulating pro-/anti-inflammatory cytokine gene expression." @default.
- W1979157547 created "2016-06-24" @default.
- W1979157547 creator A5001952947 @default.
- W1979157547 creator A5050652083 @default.
- W1979157547 date "2011-11-01" @default.
- W1979157547 modified "2023-10-18" @default.
- W1979157547 title "Lotus (Nelumbo nucifera Gaertn) plumule polysaccharide protects the spleen and liver from spontaneous inflammation in non-obese diabetic mice by modulating pro-/anti-inflammatory cytokine gene expression" @default.
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- W1979157547 doi "https://doi.org/10.1016/j.foodchem.2011.03.103" @default.
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