Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979175364> ?p ?o ?g. }
- W1979175364 endingPage "379" @default.
- W1979175364 startingPage "370" @default.
- W1979175364 abstract "Uterine leiomyomas are the most common benign gynecologic condition. The prevalence is three times more common among women of African ethnicity. Disparity in this disease is evidenced by earlier age of onset, greater severity of symptoms, and different response to treatment. Although the pathogenesis of disease development is not completely known, growing evidence focuses on investigating the molecular mechanisms in disease development and the influence of ethnicity. Variation in the expression levels or function of estrogen and progesterone receptors, polymorphism of genes involved in estrogen synthesis and/or metabolism (<i>COMT</i>, <i>CYP17</i>), retinoic acid nuclear receptors (retinoid acid receptor-α, retinoid X receptor-α), and aberrant expression of micro-RNAs (miRNAs) are some of the molecular mechanisms that may be involved. Nutritional factors, such as vitamin D deficiency, might also contribute to the higher incidence in dark skinned populations who are also commonly suffer from hypovitaminosis D. Culture and environmental difference might have a role in disease development. Further analysis and better understanding of these mechanisms will provide insight into the molecular basis of racial disparities in leiomyoma formation and will help to develop new innovations in leiomyoma treatment." @default.
- W1979175364 created "2016-06-24" @default.
- W1979175364 creator A5003343672 @default.
- W1979175364 creator A5014892375 @default.
- W1979175364 creator A5067088712 @default.
- W1979175364 date "2013-08-09" @default.
- W1979175364 modified "2023-10-01" @default.
- W1979175364 title "Racial and Ethnic Differences in the Pathogenesis and Clinical Manifestations of Uterine Leiomyoma" @default.
- W1979175364 cites W1503376671 @default.
- W1979175364 cites W1554600230 @default.
- W1979175364 cites W1616778816 @default.
- W1979175364 cites W17469937 @default.
- W1979175364 cites W1772727796 @default.
- W1979175364 cites W1948742032 @default.
- W1979175364 cites W1967105259 @default.
- W1979175364 cites W1969018878 @default.
- W1979175364 cites W1970008847 @default.
- W1979175364 cites W1972014619 @default.
- W1979175364 cites W1972422162 @default.
- W1979175364 cites W1973438143 @default.
- W1979175364 cites W1977510800 @default.
- W1979175364 cites W1980524119 @default.
- W1979175364 cites W1981199654 @default.
- W1979175364 cites W1981418867 @default.
- W1979175364 cites W1982976290 @default.
- W1979175364 cites W1988833958 @default.
- W1979175364 cites W1989225460 @default.
- W1979175364 cites W1991602076 @default.
- W1979175364 cites W1994255656 @default.
- W1979175364 cites W1995125241 @default.
- W1979175364 cites W1995381569 @default.
- W1979175364 cites W2000873474 @default.
- W1979175364 cites W2001046063 @default.
- W1979175364 cites W2003265078 @default.
- W1979175364 cites W2005902875 @default.
- W1979175364 cites W2007463943 @default.
- W1979175364 cites W2010747883 @default.
- W1979175364 cites W2011446505 @default.
- W1979175364 cites W2012784577 @default.
- W1979175364 cites W2013653552 @default.
- W1979175364 cites W2015110625 @default.
- W1979175364 cites W2019095198 @default.
- W1979175364 cites W2019527863 @default.
- W1979175364 cites W2020064845 @default.
- W1979175364 cites W2020226978 @default.
- W1979175364 cites W2021087587 @default.
- W1979175364 cites W2022779155 @default.
- W1979175364 cites W2025282165 @default.
- W1979175364 cites W2025880854 @default.
- W1979175364 cites W2026893819 @default.
- W1979175364 cites W2028151326 @default.
- W1979175364 cites W2028720415 @default.
- W1979175364 cites W2029288107 @default.
- W1979175364 cites W2029717873 @default.
- W1979175364 cites W2030676169 @default.
- W1979175364 cites W2031903809 @default.
- W1979175364 cites W2032207579 @default.
- W1979175364 cites W2032390737 @default.
- W1979175364 cites W2033540581 @default.
- W1979175364 cites W2039372194 @default.
- W1979175364 cites W2039552071 @default.
- W1979175364 cites W2048708535 @default.
- W1979175364 cites W2053377602 @default.
- W1979175364 cites W2053945121 @default.
- W1979175364 cites W2054288703 @default.
- W1979175364 cites W2054994020 @default.
- W1979175364 cites W2058727657 @default.
- W1979175364 cites W2059829212 @default.
- W1979175364 cites W2060920420 @default.
- W1979175364 cites W2062048876 @default.
- W1979175364 cites W2063193774 @default.
- W1979175364 cites W2066645560 @default.
- W1979175364 cites W2066888185 @default.
- W1979175364 cites W2069152026 @default.
- W1979175364 cites W2071600627 @default.
- W1979175364 cites W2072040977 @default.
- W1979175364 cites W2072108911 @default.
- W1979175364 cites W2073101006 @default.
- W1979175364 cites W2074700891 @default.
- W1979175364 cites W2075832132 @default.
- W1979175364 cites W2078264444 @default.
- W1979175364 cites W2079008410 @default.
- W1979175364 cites W2079959854 @default.
- W1979175364 cites W2080395332 @default.
- W1979175364 cites W2081745157 @default.
- W1979175364 cites W2082858783 @default.
- W1979175364 cites W2091700826 @default.
- W1979175364 cites W2093612217 @default.
- W1979175364 cites W2094884080 @default.
- W1979175364 cites W2097155470 @default.
- W1979175364 cites W2097846180 @default.
- W1979175364 cites W2098400976 @default.
- W1979175364 cites W2100040984 @default.
- W1979175364 cites W2101216291 @default.
- W1979175364 cites W2105187990 @default.
- W1979175364 cites W2109135866 @default.
- W1979175364 cites W2109525253 @default.
- W1979175364 cites W2109858742 @default.