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- W1979178441 abstract "Srdian Nikolic PhD, Edward L Yellin PhD, Manfred Dahm MD, Octavia Pajaro MS, Robert W.M. Frater, MD FACC. Albert Einstein College of Medicine, Bronx, NY To determine if elastic restoring forces and changes in diastolic shape influence the diastolic pres?iure-flow relation we instrumented 8 anesthetized dogs to measure mitral flow, LVP, LAP, LW from major and minor diameters, and with electronically controlled artificial mitral valve to stop filling in diastole. We determined LV shape in normal filling (F) and nonfilling (NF) beats in the presence (+ER) or absence (-ER) of elastic recoil. Development of negative LVP in NF indicated +ER. Midwall eccentricity (ECC) was related to end-diastolic (ED) and end-systolic (ES) volumes: in NF at ED: EC&,,,=-0.004OV,,,+O.98 (n=72, r=0.95) in F at ES: EC&=-0.0010V,+0.90 (n=72, r=0.93) in F at ED: EC&,=-0.0033V,,+0.99 (n=72, r=OSY) Intersection of the ES and ED lines in F (transitional volume, V,) divides ECC-V plane into two regions: for VcV, elliptical shape change and +ER: for V>V, spherical shape change and -ER. We calculated the slope (dissipative coefficient) of the linear regression through the origin of peak mitral flow squared (Q?) and the corresponding atrio-ventricular pressure gradient (PC,&. (Note that mitral ring is fixed). In F: V>V, and (-ER) PGruD= 0.00063Q~ (n==48, r=0.94) VcV, and (+ER) PGRAD= 0.000370? (n=24, r=0.96) (pcO.001) Thus, filling is more efficient in a smaller, ellipsoidal LV, in which the flow is assisted by the restoring forces." @default.
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- W1979178441 date "1990-02-01" @default.
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- W1979178441 title "Effect of left ventricular shape on diastolic pressure-flow relationship" @default.
- W1979178441 doi "https://doi.org/10.1016/0735-1097(90)92027-y" @default.
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