FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979179932> ?p ?o ?g. }

• W1979179932 abstract "Abstract Staphylococcal nuclease is a Ca2+-activated, extracellular phosphodiesterase which degrades DNA or RNA ot 3′-nucleotides. The enzyme is strongly inhibited by deoxythymidine 3′,5′-diphosphate (pdTp). The high resolution crystal structure of the nuclease-pdTp-Ca2+ complex has facilitated a proposed mechanism of action. However, attempts to test this mechanism in solution have been frustrated by the lack of non-hydrolyzable dinucleotide analogues. Here we report a novel synthesis route for several isoteric phosphonate analogues of pdTpdT. Binding and kinetic experiments show that the phosphonate derivatives competitively inhibit enzymatic activity while stabilizing the protein's tertiary conformation. A description of the active site as seen in the nuclease-dinucleoside phosphate (pcdTpcdT)-Ca2+ complex at 2.0 A resolution is presented." @default.
• W1979179932 created "2016-06-24" @default.
• W1979179932 creator A5027706234 @default.
• W1979179932 creator A5057887755 @default.
• W1979179932 creator A5066185101 @default.
• W1979179932 creator A5076019831 @default.
• W1979179932 date "1995-02-01" @default.
• W1979179932 modified "2023-09-27" @default.
• W1979179932 title "The binding of dinucleoside phosphonates in the active site of the metallo-enzyme, Staphylococcal nuclease: synthetic, solution and preliminary crystallographic studies" @default.
• W1979179932 cites W1466033174 @default.
• W1979179932 cites W1482133448 @default.
• W1979179932 cites W1496711114 @default.
• W1979179932 cites W1533780298 @default.
• W1979179932 cites W1544637166 @default.
• W1979179932 cites W1547519509 @default.
• W1979179932 cites W1618025585 @default.
• W1979179932 cites W1650694890 @default.
• W1979179932 cites W1782800388 @default.
• W1979179932 cites W1885778179 @default.
• W1979179932 cites W1967827014 @default.
• W1979179932 cites W1992398066 @default.
• W1979179932 cites W2003297566 @default.
• W1979179932 cites W2008850823 @default.
• W1979179932 cites W2014974385 @default.
• W1979179932 cites W2016973898 @default.
• W1979179932 cites W2040462725 @default.
• W1979179932 cites W2050082386 @default.
• W1979179932 cites W2054979333 @default.
• W1979179932 cites W2059627520 @default.
• W1979179932 cites W2061734875 @default.
• W1979179932 cites W2063330692 @default.
• W1979179932 cites W2065986370 @default.
• W1979179932 cites W2066546907 @default.
• W1979179932 cites W2066886482 @default.
• W1979179932 cites W2066983784 @default.
• W1979179932 cites W2072068458 @default.
• W1979179932 cites W2076217345 @default.
• W1979179932 cites W2079236986 @default.
• W1979179932 cites W2107705569 @default.
• W1979179932 cites W2312708001 @default.
• W1979179932 cites W2314516278 @default.
• W1979179932 cites W2317157760 @default.
• W1979179932 cites W2322598044 @default.
• W1979179932 cites W2412688468 @default.
• W1979179932 cites W3159921398 @default.
• W1979179932 doi "https://doi.org/10.1016/0020-1693(94)04276-2" @default.
• W1979179932 hasPublicationYear "1995" @default.
• W1979179932 type Work @default.
• W1979179932 sameAs 1979179932 @default.
• W1979179932 citedByCount "0" @default.
• W1979179932 crossrefType "journal-article" @default.
• W1979179932 hasAuthorship W1979179932A5027706234 @default.
• W1979179932 hasAuthorship W1979179932A5057887755 @default.
• W1979179932 hasAuthorship W1979179932A5066185101 @default.
• W1979179932 hasAuthorship W1979179932A5076019831 @default.
• W1979179932 hasConcept C104317684 @default.
• W1979179932 hasConcept C107824862 @default.
• W1979179932 hasConcept C181199279 @default.
• W1979179932 hasConcept C185592680 @default.
• W1979179932 hasConcept C21951064 @default.
• W1979179932 hasConcept C2777271071 @default.
• W1979179932 hasConcept C2777626080 @default.
• W1979179932 hasConcept C41183919 @default.
• W1979179932 hasConcept C512185932 @default.
• W1979179932 hasConcept C552990157 @default.
• W1979179932 hasConcept C55493867 @default.
• W1979179932 hasConcept C67705224 @default.
• W1979179932 hasConcept C71240020 @default.
• W1979179932 hasConceptScore W1979179932C104317684 @default.
• W1979179932 hasConceptScore W1979179932C107824862 @default.
• W1979179932 hasConceptScore W1979179932C181199279 @default.
• W1979179932 hasConceptScore W1979179932C185592680 @default.
• W1979179932 hasConceptScore W1979179932C21951064 @default.
• W1979179932 hasConceptScore W1979179932C2777271071 @default.
• W1979179932 hasConceptScore W1979179932C2777626080 @default.
• W1979179932 hasConceptScore W1979179932C41183919 @default.
• W1979179932 hasConceptScore W1979179932C512185932 @default.
• W1979179932 hasConceptScore W1979179932C552990157 @default.
• W1979179932 hasConceptScore W1979179932C55493867 @default.
• W1979179932 hasConceptScore W1979179932C67705224 @default.
• W1979179932 hasConceptScore W1979179932C71240020 @default.
• W1979179932 hasLocation W19791799321 @default.
• W1979179932 hasOpenAccess W1979179932 @default.
• W1979179932 hasPrimaryLocation W19791799321 @default.
• W1979179932 hasRelatedWork W1501608760 @default.
• W1979179932 hasRelatedWork W1517860401 @default.
• W1979179932 hasRelatedWork W1533945145 @default.
• W1979179932 hasRelatedWork W1576668296 @default.
• W1979179932 hasRelatedWork W1591417781 @default.
• W1979179932 hasRelatedWork W1592798976 @default.
• W1979179932 hasRelatedWork W1964789816 @default.
• W1979179932 hasRelatedWork W1967684547 @default.
• W1979179932 hasRelatedWork W1992458278 @default.
• W1979179932 hasRelatedWork W2008850823 @default.
• W1979179932 hasRelatedWork W2010223904 @default.
• W1979179932 hasRelatedWork W2019175268 @default.
• W1979179932 hasRelatedWork W2026458174 @default.
• W1979179932 hasRelatedWork W2035271351 @default.
• W1979179932 hasRelatedWork W2053037420 @default.
• W1979179932 hasRelatedWork W2114170044 @default.

• next