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- W1979183909 abstract "Objective: To determine any association between plasma coenzyme Q10 (CoQ10) and α-tocopherol levels and severity of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: Plasma levels of total CoQ10 and α-tocopherol were measured by high-performance liquid chromatography in patients with biopsy-confirmed CIN (n = 55) and cervical cancer (n = 20) and in normal women with no abnormal Pap test results (n = 27). Cervicovaginal lavages containing epithelial cells (CVC), obtained from the same subjects, also were analyzed for CoQ10 concentrations. Results: The mean plasma levels of CoQ10 and α-tocopherol were significantly (P = 0.001) lower in patients with CIN and cervical cancer compared with controls. Levels of CoQ10 from CVC were measurable and also were significantly (P = 0.001) lower in women with CIN. Conclusion: The findings suggest that CoQ10 and α-tocopherol antioxidants may play a role in the pathogenesis of CIN. The decrease in CoQ10 and α-tocopherol levels may be caused by deficient dietary intake in women with CIN. Alternatively, low antioxidant levels may reflect increased utilization to counteract oxidative stress." @default.
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- W1979183909 date "2001-05-01" @default.
- W1979183909 modified "2023-09-27" @default.
- W1979183909 title "Coenzyme Q10 and α-tocopherol concentrations in cervical intraepithelial neoplasia and cervix cancer" @default.
- W1979183909 doi "https://doi.org/10.1016/s0029-7844(01)01135-8" @default.
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