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• W1979184180 abstract "Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model of peritoneal sepsis. These results may explain the low incidence and dissemination of colistin resistance in A. baumannii in clinical settings." @default.
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• W1979184180 date "2011-01-07" @default.
• W1979184180 modified "2023-10-13" @default.
• W1979184180 title "Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii" @default.
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• W1979184180 doi "https://doi.org/10.1093/infdis/jiq086" @default.
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