FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979193732> ?p ?o ?g. }

• W1979193732 abstract "Glucocorticoids depress bone formation by inhibiting osteoblastogenesis and increasing osteoblast apoptosis. However, the role of bone resorption in the initial rapid phase of bone loss characteristic of glucocorticoid-induced osteoporosis is unexplained, and the reason for the efficacy of bisphosphonates in this condition remains unknown. We report that in murine osteoclast cultures, glucocorticoids prolonged the baseline survival of osteoclasts and antagonized bisphosphonate-induced caspase activation and apoptosis by a glucocorticoid receptor-mediated action. Consistent with the in vitro evidence, in a murine model of glucocorticoid-induced osteoporosis, the number of cancellous osteoclasts increased, even though osteoclast progenitor number was reduced. Moreover, in mice receiving both glucocorticoids and bisphosphonates, the expected proapoptotic effect of bisphosphonates on osteoclasts was abrogated, as evidenced by maintenance of osteoclast numbers and, additionally, loss of bone density. In contrast, bisphosphonate administration prevented glucocorticoid-induced osteoblast apoptosis. These results indicate that the early loss of bone with glucocorticoid excess is caused by extension of the life span of pre-existing osteoclasts, an effect not preventable by bisphosphonates. Therefore, the early beneficial effects of these agents must be due, in part, to prolonging the life span of osteoblasts." @default.
• W1979193732 created "2016-06-24" @default.
• W1979193732 creator A5000727397 @default.
• W1979193732 creator A5011446671 @default.
• W1979193732 creator A5019660823 @default.
• W1979193732 creator A5027634434 @default.
• W1979193732 creator A5053404897 @default.
• W1979193732 creator A5054118361 @default.
• W1979193732 creator A5054572577 @default.
• W1979193732 creator A5057132952 @default.
• W1979193732 creator A5082213953 @default.
• W1979193732 date "2002-04-15" @default.
• W1979193732 modified "2023-10-17" @default.
• W1979193732 title "Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids" @default.
• W1979193732 cites W1557762633 @default.
• W1979193732 cites W1972472172 @default.
• W1979193732 cites W1972567404 @default.
• W1979193732 cites W1984670018 @default.
• W1979193732 cites W1989048614 @default.
• W1979193732 cites W1999997785 @default.
• W1979193732 cites W2002315967 @default.
• W1979193732 cites W2008341503 @default.
• W1979193732 cites W2015159818 @default.
• W1979193732 cites W2016674232 @default.
• W1979193732 cites W2064279221 @default.
• W1979193732 cites W2085392426 @default.
• W1979193732 cites W2087378917 @default.
• W1979193732 cites W2090173854 @default.
• W1979193732 cites W2093164779 @default.
• W1979193732 cites W2096324771 @default.
• W1979193732 cites W2099531123 @default.
• W1979193732 cites W2107571929 @default.
• W1979193732 cites W2118534072 @default.
• W1979193732 cites W2128261464 @default.
• W1979193732 cites W2132646563 @default.
• W1979193732 cites W2134460604 @default.
• W1979193732 cites W2135202875 @default.
• W1979193732 cites W2137112407 @default.
• W1979193732 cites W2142820105 @default.
• W1979193732 cites W2144957471 @default.
• W1979193732 cites W2149707203 @default.
• W1979193732 cites W2149742062 @default.
• W1979193732 cites W2149946235 @default.
• W1979193732 cites W2153869151 @default.
• W1979193732 cites W2158254263 @default.
• W1979193732 cites W2170595983 @default.
• W1979193732 cites W2170680219 @default.
• W1979193732 cites W2314674563 @default.
• W1979193732 cites W2336040302 @default.
• W1979193732 doi "https://doi.org/10.1172/jci14538" @default.
• W1979193732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/150947" @default.
• W1979193732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11956241" @default.
• W1979193732 hasPublicationYear "2002" @default.
• W1979193732 type Work @default.
• W1979193732 sameAs 1979193732 @default.
• W1979193732 citedByCount "132" @default.
• W1979193732 countsByYear W19791937322012 @default.
• W1979193732 countsByYear W19791937322013 @default.
• W1979193732 countsByYear W19791937322014 @default.
• W1979193732 countsByYear W19791937322015 @default.
• W1979193732 countsByYear W19791937322016 @default.
• W1979193732 countsByYear W19791937322017 @default.
• W1979193732 countsByYear W19791937322018 @default.
• W1979193732 countsByYear W19791937322019 @default.
• W1979193732 countsByYear W19791937322020 @default.
• W1979193732 countsByYear W19791937322021 @default.
• W1979193732 countsByYear W19791937322022 @default.
• W1979193732 countsByYear W19791937322023 @default.
• W1979193732 crossrefType "journal-article" @default.
• W1979193732 hasAuthorship W1979193732A5000727397 @default.
• W1979193732 hasAuthorship W1979193732A5011446671 @default.
• W1979193732 hasAuthorship W1979193732A5019660823 @default.
• W1979193732 hasAuthorship W1979193732A5027634434 @default.
• W1979193732 hasAuthorship W1979193732A5053404897 @default.
• W1979193732 hasAuthorship W1979193732A5054118361 @default.
• W1979193732 hasAuthorship W1979193732A5054572577 @default.
• W1979193732 hasAuthorship W1979193732A5057132952 @default.
• W1979193732 hasAuthorship W1979193732A5082213953 @default.
• W1979193732 hasBestOaLocation W19791937321 @default.
• W1979193732 hasConcept C126322002 @default.
• W1979193732 hasConcept C134018914 @default.
• W1979193732 hasConcept C146562846 @default.
• W1979193732 hasConcept C170493617 @default.
• W1979193732 hasConcept C185592680 @default.
• W1979193732 hasConcept C190283241 @default.
• W1979193732 hasConcept C201750760 @default.
• W1979193732 hasConcept C202751555 @default.
• W1979193732 hasConcept C2776033226 @default.
• W1979193732 hasConcept C2776541429 @default.
• W1979193732 hasConcept C2777251235 @default.
• W1979193732 hasConcept C2778260815 @default.
• W1979193732 hasConcept C2780841215 @default.
• W1979193732 hasConcept C28328180 @default.
• W1979193732 hasConcept C502942594 @default.
• W1979193732 hasConcept C55493867 @default.
• W1979193732 hasConcept C673006 @default.
• W1979193732 hasConcept C71924100 @default.
• W1979193732 hasConcept C86803240 @default.
• W1979193732 hasConcept C95444343 @default.
• W1979193732 hasConceptScore W1979193732C126322002 @default.

• next