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- W1979196905 abstract "Summary In numerous mammals, nitric oxide (NO) influences the activity of the exocrine and endocrine pancreas. In this study, immunocytochemistry was utilized to investigate the expression of neuronal nitric oxide synthase (nNOS) in the pancreas of sheep. In double immunocytochemical staining, the co‐localization of nNOS with vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY) or substance P (SP) was studied. The presence of nNOS was confined to the intrapancreatic neurones (9.6 ± 1.3%) as well as to nerve fibres of the endocrine pancreas and intrapancreatic ganglia. nNOS‐immunoreactive (IR) neurones were round and oval in shape and predominantly (83.3 ± 2.6%) belonged to the middle‐size group (25–50 μ m). Numerous, fine islets supplying nNOS‐IR nerve terminals were devoid of VIP, SP or NPY. Moderately numerous, non‐varicose nNOS‐IR nerve fibres of intrapancreatic ganglia frequently expressed VIP or NPY, but not SP; 2.2 ± 0.6% of nNOS‐IR intrapancreatic neurones displayed lack of VIP, whereas 7.5 ± 0.8% were VIP‐IR. All nNOS‐IR neurones were devoid of SP. The frequencies of nNOS‐IR/NPY‐IR and nNOS‐IR/NPY‐negative intrapancreatic neurones were 2.2 ± 0.4% and 6.1 ± 1.1%, respectively. Comparison with other mammals indicated that nitrergic innervation of the ovine pancreas is species‐determined and may be a reflection of the ruminants’ digestion specificity. The possible origin of nNOS‐IR nerve fibres and functional significance of NO in the pancreas of sheep were discussed." @default.
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- W1979196905 date "2007-06-21" @default.
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- W1979196905 title "Expression of Neuronal Nitric Oxide Synthase in the Pancreas of the Sheep" @default.
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- W1979196905 doi "https://doi.org/10.1111/j.1439-0264.2007.00777.x" @default.
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