FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979199696> ?p ?o ?g. }

• W1979199696 endingPage "183" @default.
• W1979199696 startingPage "176" @default.
• W1979199696 abstract "The purpose of this study was to investigate in vitro the potential effect of type 1 collagen gel containing alpha-elastin on the proliferation of vascular smooth muscle cells and vascular endothelial cells, and on smooth muscle cell migration. Vascular smooth muscle cell and endothelial cell were cultured in 12-well plates precoated with collagen gels and alpha-elastin. Cell proliferation rates were measured by monitoring [3H]-thymidine incorporation. After 2, 3 or 4 days of culture, the proliferation rate of both smooth muscle cells and endothelial cells was significantly decreased on collagen gel containing 10 mg/ml alpha-elastin compared with collagen gel only as control. Smooth muscle cell proliferation on collagen gel containing alpha-elastin on the 4th day of culture was decreased dose-dependently, e.g. 1 mg/ml of alpha-elastin (74.8(2.3)% of control, P=n.s.); 5 mg/ml (56.7(2.1)%; P<0.05); 10 mg/ml (30.3(3.1)%; P<0.005). In the case of cultured endothelial cells, however, [3H]-thymidine incorporation was not decreased significantly in the presence of 5 mg/ml alpha-elastin (83.1(7.9)%, P=n.s.). After stimulation by platelet-derived growth factor, the smooth muscle cell migration rate on collagen gel containing alpha-elastin (5 mg/ml) was decreased over time. The area of migration on the 6th day of culture was also significantly decreased dose-dependently in the presence of alpha-elastin, e.g. 1 mg/ml (72.6(3.4)% of control, P<0.05), 5 mg/ml (56.9%(1.5)%; P<0.05); 10 mg/ml (37.3(2.7)%; P<0.0005). In conclusion, alpha-elastin inhibited the proliferation and migration of smooth muscle cell in a dose-dependent manner on collagen gel culture, however, at high concentrations of alpha-elastin (10 mg/ml), the endothelial cell proliferation rate was also inhibited. At 5 mg/ml, alpha-elastin significantly inhibited smooth muscle cell proliferation and migration but did not significantly inhibit endothelial cell proliferation. Incorporation of collagen gel containing alpha-elastin into the structure of arterial prosthesis offers the possibility of inhibiting smooth muscle cell hyperplasia without significant effect on endothelial cell formation." @default.
• W1979199696 created "2016-06-24" @default.
• W1979199696 creator A5021620288 @default.
• W1979199696 creator A5077589653 @default.
• W1979199696 creator A5086685397 @default.
• W1979199696 date "1997-04-01" @default.
• W1979199696 modified "2023-09-29" @default.
• W1979199696 title "Inhibitory effect of type 1 collagen gel containing α-elastin on proliferation and migration of vascular smooth muscle and endothelial cells" @default.
• W1979199696 cites W1530612865 @default.
• W1979199696 cites W1957628343 @default.
• W1979199696 cites W1974203601 @default.
• W1979199696 cites W1984197852 @default.
• W1979199696 cites W1985822484 @default.
• W1979199696 cites W1998689385 @default.
• W1979199696 cites W2015216741 @default.
• W1979199696 cites W2016218168 @default.
• W1979199696 cites W2038594750 @default.
• W1979199696 cites W2047719165 @default.
• W1979199696 cites W2047733245 @default.
• W1979199696 cites W2050978899 @default.
• W1979199696 cites W2057078286 @default.
• W1979199696 cites W2062199482 @default.
• W1979199696 cites W2088468623 @default.
• W1979199696 cites W2137114048 @default.
• W1979199696 cites W2155255246 @default.
• W1979199696 cites W2158979977 @default.
• W1979199696 cites W2168225642 @default.
• W1979199696 cites W2170460001 @default.
• W1979199696 cites W2338996958 @default.
• W1979199696 doi "https://doi.org/10.1016/s0967-2109(97)00004-5" @default.
• W1979199696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9212204" @default.
• W1979199696 hasPublicationYear "1997" @default.
• W1979199696 type Work @default.
• W1979199696 sameAs 1979199696 @default.
• W1979199696 citedByCount "32" @default.
• W1979199696 countsByYear W19791996962012 @default.
• W1979199696 countsByYear W19791996962013 @default.
• W1979199696 countsByYear W19791996962014 @default.
• W1979199696 countsByYear W19791996962015 @default.
• W1979199696 countsByYear W19791996962016 @default.
• W1979199696 countsByYear W19791996962018 @default.
• W1979199696 countsByYear W19791996962020 @default.
• W1979199696 countsByYear W19791996962022 @default.
• W1979199696 crossrefType "journal-article" @default.
• W1979199696 hasAuthorship W1979199696A5021620288 @default.
• W1979199696 hasAuthorship W1979199696A5077589653 @default.
• W1979199696 hasAuthorship W1979199696A5086685397 @default.
• W1979199696 hasConcept C123012128 @default.
• W1979199696 hasConcept C134018914 @default.
• W1979199696 hasConcept C142724271 @default.
• W1979199696 hasConcept C153911025 @default.
• W1979199696 hasConcept C185592680 @default.
• W1979199696 hasConcept C202751555 @default.
• W1979199696 hasConcept C2779395532 @default.
• W1979199696 hasConcept C2779869378 @default.
• W1979199696 hasConcept C2780644872 @default.
• W1979199696 hasConcept C2992686903 @default.
• W1979199696 hasConcept C55493867 @default.
• W1979199696 hasConcept C62112901 @default.
• W1979199696 hasConcept C71924100 @default.
• W1979199696 hasConcept C86803240 @default.
• W1979199696 hasConceptScore W1979199696C123012128 @default.
• W1979199696 hasConceptScore W1979199696C134018914 @default.
• W1979199696 hasConceptScore W1979199696C142724271 @default.
• W1979199696 hasConceptScore W1979199696C153911025 @default.
• W1979199696 hasConceptScore W1979199696C185592680 @default.
• W1979199696 hasConceptScore W1979199696C202751555 @default.
• W1979199696 hasConceptScore W1979199696C2779395532 @default.
• W1979199696 hasConceptScore W1979199696C2779869378 @default.
• W1979199696 hasConceptScore W1979199696C2780644872 @default.
• W1979199696 hasConceptScore W1979199696C2992686903 @default.
• W1979199696 hasConceptScore W1979199696C55493867 @default.
• W1979199696 hasConceptScore W1979199696C62112901 @default.
• W1979199696 hasConceptScore W1979199696C71924100 @default.
• W1979199696 hasConceptScore W1979199696C86803240 @default.
• W1979199696 hasIssue "2" @default.
• W1979199696 hasLocation W19791996961 @default.
• W1979199696 hasLocation W19791996962 @default.
• W1979199696 hasOpenAccess W1979199696 @default.
• W1979199696 hasPrimaryLocation W19791996961 @default.
• W1979199696 hasRelatedWork W1976095289 @default.
• W1979199696 hasRelatedWork W1979199696 @default.
• W1979199696 hasRelatedWork W2021318962 @default.
• W1979199696 hasRelatedWork W2031471867 @default.
• W1979199696 hasRelatedWork W2110284835 @default.
• W1979199696 hasRelatedWork W2177115029 @default.
• W1979199696 hasRelatedWork W2322697117 @default.
• W1979199696 hasRelatedWork W2516619839 @default.
• W1979199696 hasRelatedWork W2748952813 @default.
• W1979199696 hasRelatedWork W4226102372 @default.
• W1979199696 hasVolume "5" @default.
• W1979199696 isParatext "false" @default.
• W1979199696 isRetracted "false" @default.
• W1979199696 magId "1979199696" @default.
• W1979199696 workType "article" @default.