Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979205923> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1979205923 endingPage "707" @default.
- W1979205923 startingPage "702" @default.
- W1979205923 abstract "Background: In the past few years, low doses of methotrexate have been used for treatment of patients with rheumatoid arthritis and other collagen vascular diseases, mainly as an immunosuppressive and corticosteroid-sparing drug. Several cutaneous adverse reactions have been described in association with methotrexate therapy. Objective: We describe the clinical and the histopathologic features of distinctive cutaneous lesions that appeared in 4 patients with acute bouts of collagen vascular diseases who were receiving methotrexate therapy. Methods: We clinically and histopathologically evaluated cutaneous lesions caused by methotrexate therapy in 4 patients, 2 with systemic lupus erythematosus, 1 with rheumatoid arthritis, and 1 with Sharp syndrome. Results: Clinically, lesions consisted of erythematous indurated papules most commonly located on proximal areas of the extremities. Histopathologic examination of these papules showed an inflammatory infiltrate mainly composed of histiocytes interstitially arranged between collagen bundles of the dermis, intermingled with few neutrophils. In some foci of deeper reticular dermis, small rosettes composed of clusters of histiocytes surrounding a thick central collagen bundle were seen. Cutaneous lesions showed a direct chronologic relationship with methotrexate therapy, and they disappeared when the drug was tapered or withdrawn and corticosteroids were increased. Conclusion: Patients receiving low doses of methotrexate for acute bouts of collagen vascular diseases may experience characteristic cutaneous lesions with distinctive clinical and histopathologic findings shortly after methotrexate administration. We discuss the differential diagnosis with other dermatoses showing similar histopathologic findings that have been described in patients with collagen vascular diseases.(J Am Acad Dermatol 1999;40:702-7.)" @default.
- W1979205923 created "2016-06-24" @default.
- W1979205923 creator A5006327773 @default.
- W1979205923 creator A5008472341 @default.
- W1979205923 creator A5079167470 @default.
- W1979205923 creator A5082098822 @default.
- W1979205923 date "1999-05-01" @default.
- W1979205923 modified "2023-09-23" @default.
- W1979205923 title "Methotrexate-induced papular eruption in patients with rheumatic diseases: A distinctive adverse cutaneous reaction produced by methotrexate in patients with collagen vascular diseases" @default.
- W1979205923 cites W1976730809 @default.
- W1979205923 cites W1977194406 @default.
- W1979205923 cites W1984135181 @default.
- W1979205923 cites W1994063231 @default.
- W1979205923 cites W1999623813 @default.
- W1979205923 cites W2001812121 @default.
- W1979205923 cites W2009963750 @default.
- W1979205923 cites W2012106745 @default.
- W1979205923 cites W2012850200 @default.
- W1979205923 cites W2024324377 @default.
- W1979205923 cites W2044535810 @default.
- W1979205923 cites W2068597002 @default.
- W1979205923 cites W2072504052 @default.
- W1979205923 cites W2087698686 @default.
- W1979205923 cites W2151465424 @default.
- W1979205923 doi "https://doi.org/10.1016/s0190-9622(99)70150-7" @default.
- W1979205923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10321597" @default.
- W1979205923 hasPublicationYear "1999" @default.
- W1979205923 type Work @default.
- W1979205923 sameAs 1979205923 @default.
- W1979205923 citedByCount "48" @default.
- W1979205923 countsByYear W19792059232012 @default.
- W1979205923 countsByYear W19792059232013 @default.
- W1979205923 countsByYear W19792059232014 @default.
- W1979205923 countsByYear W19792059232015 @default.
- W1979205923 countsByYear W19792059232016 @default.
- W1979205923 countsByYear W19792059232018 @default.
- W1979205923 countsByYear W19792059232020 @default.
- W1979205923 countsByYear W19792059232021 @default.
- W1979205923 countsByYear W19792059232022 @default.
- W1979205923 crossrefType "journal-article" @default.
- W1979205923 hasAuthorship W1979205923A5006327773 @default.
- W1979205923 hasAuthorship W1979205923A5008472341 @default.
- W1979205923 hasAuthorship W1979205923A5079167470 @default.
- W1979205923 hasAuthorship W1979205923A5082098822 @default.
- W1979205923 hasConcept C126322002 @default.
- W1979205923 hasConcept C142724271 @default.
- W1979205923 hasConcept C16005928 @default.
- W1979205923 hasConcept C2777077863 @default.
- W1979205923 hasConcept C2777575956 @default.
- W1979205923 hasConcept C2777624698 @default.
- W1979205923 hasConcept C2779134260 @default.
- W1979205923 hasConcept C2781059491 @default.
- W1979205923 hasConcept C3020327254 @default.
- W1979205923 hasConcept C43100952 @default.
- W1979205923 hasConcept C71924100 @default.
- W1979205923 hasConceptScore W1979205923C126322002 @default.
- W1979205923 hasConceptScore W1979205923C142724271 @default.
- W1979205923 hasConceptScore W1979205923C16005928 @default.
- W1979205923 hasConceptScore W1979205923C2777077863 @default.
- W1979205923 hasConceptScore W1979205923C2777575956 @default.
- W1979205923 hasConceptScore W1979205923C2777624698 @default.
- W1979205923 hasConceptScore W1979205923C2779134260 @default.
- W1979205923 hasConceptScore W1979205923C2781059491 @default.
- W1979205923 hasConceptScore W1979205923C3020327254 @default.
- W1979205923 hasConceptScore W1979205923C43100952 @default.
- W1979205923 hasConceptScore W1979205923C71924100 @default.
- W1979205923 hasIssue "5" @default.
- W1979205923 hasLocation W19792059231 @default.
- W1979205923 hasLocation W19792059232 @default.
- W1979205923 hasOpenAccess W1979205923 @default.
- W1979205923 hasPrimaryLocation W19792059231 @default.
- W1979205923 hasRelatedWork W1977601919 @default.
- W1979205923 hasRelatedWork W1979205923 @default.
- W1979205923 hasRelatedWork W2001317021 @default.
- W1979205923 hasRelatedWork W2010781105 @default.
- W1979205923 hasRelatedWork W2055140067 @default.
- W1979205923 hasRelatedWork W2347757225 @default.
- W1979205923 hasRelatedWork W2362264087 @default.
- W1979205923 hasRelatedWork W3028922123 @default.
- W1979205923 hasRelatedWork W4243523147 @default.
- W1979205923 hasRelatedWork W4318598683 @default.
- W1979205923 hasVolume "40" @default.
- W1979205923 isParatext "false" @default.
- W1979205923 isRetracted "false" @default.
- W1979205923 magId "1979205923" @default.
- W1979205923 workType "article" @default.