FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979206942> ?p ?o ?g. }

• W1979206942 endingPage "4187" @default.
• W1979206942 startingPage "4180" @default.
• W1979206942 abstract "Abstract Peptides containing the Arg-Gly-Asp (RGD) motif inhibit cell adhesion and exhibit a variety of other biologic effects including anticoagulant and antimetastatic activities. The aim of the present study was to examine the anchorage-independent effects of an RGD-containing peptide, Arg-Gly-Asp-Ser (RGDS), on human umbilical vein endothelial cells (HUVECs). Assays were performed on HUVECs seeded onto collagen IV; under these experimental conditions RGDS did not exert antiadhesive effects but significantly reduced FGF-2-dependent chemotaxis after 4 hours of treatment and reduced proliferation after 24 hours of treatment. Experiments carried out with caspase-specific inhibitors indicated that the observed antichemotactic effects required caspase 8 and caspase 9 activation. RGDS activated both caspase 8 and caspase 9 after 4 hours of treatment and caspase 3 after 24 hours of treatment, and markedly enhanced HUVEC apoptosis by transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL)/Hoechst staining and fluorescence-activated cell sorting (FACS) analysis. Finally, confocal microscopy showed that RGDS localizes in the cytoplasm of live HUVECs within 4 hours and in vitro experiments showed that RGDS directly interacts with recombinant caspases 8 and 9 in a specific way. In summary, these results indicate that RGDS directly binds and activates caspases 8 and 9, inhibits chemotaxis, and induces apoptosis of HUVECs with a mechanism independent from its antiadhesive effect." @default.
• W1979206942 created "2016-06-24" @default.
• W1979206942 creator A5000156462 @default.
• W1979206942 creator A5041429982 @default.
• W1979206942 creator A5045773106 @default.
• W1979206942 creator A5048926232 @default.
• W1979206942 creator A5063574824 @default.
• W1979206942 creator A5066177292 @default.
• W1979206942 creator A5067780814 @default.
• W1979206942 creator A5078192005 @default.
• W1979206942 date "2004-06-01" @default.
• W1979206942 modified "2023-10-01" @default.
• W1979206942 title "RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells" @default.
• W1979206942 cites W143263963 @default.
• W1979206942 cites W1501984325 @default.
• W1979206942 cites W1522674317 @default.
• W1979206942 cites W159024916 @default.
• W1979206942 cites W1598400049 @default.
• W1979206942 cites W1667478348 @default.
• W1979206942 cites W183719174 @default.
• W1979206942 cites W1969891188 @default.
• W1979206942 cites W1970462654 @default.
• W1979206942 cites W1971040598 @default.
• W1979206942 cites W1972325477 @default.
• W1979206942 cites W1975857526 @default.
• W1979206942 cites W1976385326 @default.
• W1979206942 cites W1978383903 @default.
• W1979206942 cites W1980193980 @default.
• W1979206942 cites W1983967012 @default.
• W1979206942 cites W1984715051 @default.
• W1979206942 cites W1984910671 @default.
• W1979206942 cites W1986481654 @default.
• W1979206942 cites W1987781184 @default.
• W1979206942 cites W1988479585 @default.
• W1979206942 cites W1989145212 @default.
• W1979206942 cites W1990105301 @default.
• W1979206942 cites W1996114718 @default.
• W1979206942 cites W2001753204 @default.
• W1979206942 cites W2015651255 @default.
• W1979206942 cites W2021729172 @default.
• W1979206942 cites W2022814481 @default.
• W1979206942 cites W2029141691 @default.
• W1979206942 cites W2032843301 @default.
• W1979206942 cites W2041959870 @default.
• W1979206942 cites W2046176211 @default.
• W1979206942 cites W2061052708 @default.
• W1979206942 cites W2063434802 @default.
• W1979206942 cites W2064484291 @default.
• W1979206942 cites W2065150630 @default.
• W1979206942 cites W2068365812 @default.
• W1979206942 cites W2068812138 @default.
• W1979206942 cites W2070308683 @default.
• W1979206942 cites W2078761996 @default.
• W1979206942 cites W2081950547 @default.
• W1979206942 cites W2083906562 @default.
• W1979206942 cites W2085291167 @default.
• W1979206942 cites W2086992732 @default.
• W1979206942 cites W2094844458 @default.
• W1979206942 cites W2107536122 @default.
• W1979206942 cites W2117540279 @default.
• W1979206942 cites W2121807107 @default.
• W1979206942 cites W2125046292 @default.
• W1979206942 cites W2128675390 @default.
• W1979206942 cites W2134851 @default.
• W1979206942 cites W2150182870 @default.
• W1979206942 cites W2153084734 @default.
• W1979206942 cites W2153149551 @default.
• W1979206942 cites W2156044891 @default.
• W1979206942 cites W2156473142 @default.
• W1979206942 cites W2160749417 @default.
• W1979206942 cites W2167956058 @default.
• W1979206942 cites W2170883020 @default.
• W1979206942 cites W2171894706 @default.
• W1979206942 cites W2273655965 @default.
• W1979206942 cites W2291281038 @default.
• W1979206942 cites W2395047360 @default.
• W1979206942 cites W4213141530 @default.
• W1979206942 cites W4214835361 @default.
• W1979206942 cites W4250893695 @default.
• W1979206942 doi "https://doi.org/10.1182/blood-2003-06-2144" @default.
• W1979206942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14982875" @default.
• W1979206942 hasPublicationYear "2004" @default.
• W1979206942 type Work @default.
• W1979206942 sameAs 1979206942 @default.
• W1979206942 citedByCount "68" @default.
• W1979206942 countsByYear W19792069422012 @default.
• W1979206942 countsByYear W19792069422013 @default.
• W1979206942 countsByYear W19792069422014 @default.
• W1979206942 countsByYear W19792069422016 @default.
• W1979206942 countsByYear W19792069422017 @default.
• W1979206942 countsByYear W19792069422018 @default.
• W1979206942 countsByYear W19792069422019 @default.
• W1979206942 countsByYear W19792069422020 @default.
• W1979206942 countsByYear W19792069422021 @default.
• W1979206942 crossrefType "journal-article" @default.
• W1979206942 hasAuthorship W1979206942A5000156462 @default.
• W1979206942 hasAuthorship W1979206942A5041429982 @default.
• W1979206942 hasAuthorship W1979206942A5045773106 @default.

• next