FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979211041> ?p ?o ?g. }

• W1979211041 endingPage "472" @default.
• W1979211041 startingPage "461" @default.
• W1979211041 abstract "Deep dorsal horn neurons present plateau properties involved in non-linear integration of nociceptive inputs, in the windup of the discharge, and in the expression of long-lasting afterdischarges. In vitro experiments using intracellular recordings in a slice preparation of the rat spinal cord have established that they are supported in part by voltage-dependent calcium currents, and positively modulated by metabotropic glutamate receptor activation. In the present study, whole-cell patch-clamp recordings in acutely isolated soma of dorsal horn neurons (n=48) were used to analyse the voltage-dependent calcium currents involved. Deep dorsal horn neurons expressed both inactivating and non-inactivating calcium currents with Ca2+ or Ba2+ used as a charge carrier. The non-inactivating component activated at intermediate threshold (−55 mV), and was blocked mostly by nifedipine (61±6%). Although voltage-dependent facilitation of whole-cell calcium currents could be obtained by prepulses to +100 mV, repetitive depolarization at potentials compatible with the plateau (−45 mV and −10 mV) failed to induce facilitation of calcium currents. No direct modulation of somatic calcium currents by application of (S)-3,5-dihydroxyphenylglycine, a selective group I metabotropic glutamate receptor agonist and 1S,3R-1-amino-1,3-cyclopentanedicarboxylic acid, a group I and II metabotropic glutamate receptor agonist, was found, while application of the metabotropic GABAB receptor agonist baclofen induced a significant decrease in calcium currents. Thus, the present voltage-clamp study shows that rat deep dorsal horn neurons express a non-inactivating, nifedipine sensitive, intermediate threshold (−55 mV) calcium current which could provide the depolarizing drive to generate plateau potentials near threshold. Our results also indicate that calcium currents are not sensitized following repetitive stimulation, and not modulated by metabotropic glutamate receptor activation. They provide, however, the first evidence for a direct modulation of voltage-gated calcium channels in dorsal horn neurons by GABAB receptor activation, which may contribute to the mechanism of baclofen’s antinociceptive activity." @default.
• W1979211041 created "2016-06-24" @default.
• W1979211041 creator A5068907646 @default.
• W1979211041 creator A5074139503 @default.
• W1979211041 date "2001-01-01" @default.
• W1979211041 modified "2023-09-23" @default.
• W1979211041 title "Sustained l-type calcium currents in dissociated deep dorsal horn neurons of the rat: characteristics and modulation" @default.
• W1979211041 cites W1486039058 @default.
• W1979211041 cites W1520027060 @default.
• W1979211041 cites W1526580466 @default.
• W1979211041 cites W1548031896 @default.
• W1979211041 cites W1563289295 @default.
• W1979211041 cites W1599152594 @default.
• W1979211041 cites W1691247107 @default.
• W1979211041 cites W1761965274 @default.
• W1979211041 cites W1814882149 @default.
• W1979211041 cites W1968124094 @default.
• W1979211041 cites W1971336111 @default.
• W1979211041 cites W1979903825 @default.
• W1979211041 cites W1983423336 @default.
• W1979211041 cites W1995103584 @default.
• W1979211041 cites W2002219675 @default.
• W1979211041 cites W2013029538 @default.
• W1979211041 cites W2013519188 @default.
• W1979211041 cites W2018327597 @default.
• W1979211041 cites W2018601847 @default.
• W1979211041 cites W2023065608 @default.
• W1979211041 cites W2025841456 @default.
• W1979211041 cites W2029674614 @default.
• W1979211041 cites W2034286178 @default.
• W1979211041 cites W2035331415 @default.
• W1979211041 cites W2038562716 @default.
• W1979211041 cites W2041120958 @default.
• W1979211041 cites W2050760821 @default.
• W1979211041 cites W2051279593 @default.
• W1979211041 cites W2065831215 @default.
• W1979211041 cites W2069293933 @default.
• W1979211041 cites W2070841646 @default.
• W1979211041 cites W2075285126 @default.
• W1979211041 cites W2078575707 @default.
• W1979211041 cites W2079013660 @default.
• W1979211041 cites W2079173805 @default.
• W1979211041 cites W2079283223 @default.
• W1979211041 cites W2086894916 @default.
• W1979211041 cites W2092855048 @default.
• W1979211041 cites W2099626282 @default.
• W1979211041 cites W2115117267 @default.
• W1979211041 cites W2116680611 @default.
• W1979211041 cites W2121785350 @default.
• W1979211041 cites W2151683710 @default.
• W1979211041 cites W2157100401 @default.
• W1979211041 cites W2167563378 @default.
• W1979211041 cites W2169949212 @default.
• W1979211041 cites W2170912183 @default.
• W1979211041 cites W2176870190 @default.
• W1979211041 cites W2178459653 @default.
• W1979211041 cites W2249998679 @default.
• W1979211041 cites W2259214560 @default.
• W1979211041 cites W2281944866 @default.
• W1979211041 cites W2284097862 @default.
• W1979211041 cites W2329923109 @default.
• W1979211041 cites W2401543509 @default.
• W1979211041 cites W2405023198 @default.
• W1979211041 cites W2409860536 @default.
• W1979211041 cites W2411800882 @default.
• W1979211041 cites W2443717624 @default.
• W1979211041 cites W4243836117 @default.
• W1979211041 doi "https://doi.org/10.1016/s0306-4522(00)00468-1" @default.
• W1979211041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11166132" @default.
• W1979211041 hasPublicationYear "2001" @default.
• W1979211041 type Work @default.
• W1979211041 sameAs 1979211041 @default.
• W1979211041 citedByCount "30" @default.
• W1979211041 countsByYear W19792110412012 @default.
• W1979211041 countsByYear W19792110412013 @default.
• W1979211041 countsByYear W19792110412015 @default.
• W1979211041 countsByYear W19792110412016 @default.
• W1979211041 countsByYear W19792110412017 @default.
• W1979211041 crossrefType "journal-article" @default.
• W1979211041 hasAuthorship W1979211041A5068907646 @default.
• W1979211041 hasAuthorship W1979211041A5074139503 @default.
• W1979211041 hasConcept C100837961 @default.
• W1979211041 hasConcept C101027131 @default.
• W1979211041 hasConcept C12554922 @default.
• W1979211041 hasConcept C147944092 @default.
• W1979211041 hasConcept C169760540 @default.
• W1979211041 hasConcept C170493617 @default.
• W1979211041 hasConcept C178790620 @default.
• W1979211041 hasConcept C185263204 @default.
• W1979211041 hasConcept C185592680 @default.
• W1979211041 hasConcept C18699975 @default.
• W1979211041 hasConcept C26702167 @default.
• W1979211041 hasConcept C2776032975 @default.
• W1979211041 hasConcept C2777756961 @default.
• W1979211041 hasConcept C2778938600 @default.
• W1979211041 hasConcept C30979828 @default.
• W1979211041 hasConcept C35599011 @default.
• W1979211041 hasConcept C49051014 @default.

• next