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- W1979211313 abstract "Secondary brain tumor (SBT) is a devastating complication of cranial irradiation (CI). We reviewed the literature to determine the incidence of SBT as related to specific radiation therapy (RT) treatment modalities. The relative risk of radiation-associated SBT after conventional and conformal RT is well established and ranges from 5.65 to 10.9; latent time to develop second tumor ranges from 5.8 to 22.4 years, depending on radiation dose and primary disease. Theories and dosimetric models suggest that intensity-modulated radiation therapy may result in an increased risk of SBT, but clinical evidence is limited. The incidence of stereotactic radiosurgery-related SBT is low. Initial data suggest that no increased risk from proton therapy and dosimetric models predict a lower incidence of SBT compared with photons. In conclusion, the incidence of SBT related to CI is low. Longer follow-up is needed to clarify the impact of intensity-modulated radiation therapy, proton therapy and other developing technologies." @default.
- W1979211313 created "2016-06-24" @default.
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- W1979211313 date "2014-12-06" @default.
- W1979211313 modified "2023-10-01" @default.
- W1979211313 title "The incidence of second brain tumors related to cranial irradiation" @default.
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- W1979211313 doi "https://doi.org/10.1586/14737140.2015.989839" @default.
- W1979211313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25482749" @default.
- W1979211313 hasPublicationYear "2014" @default.
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