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- W1979222777 endingPage "749" @default.
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- W1979222777 abstract "Abstract The role of inherited and somatic mutations of mitochondrial DNA (mtDNA) in aging and longevity is complex and highly controversial, owing to its peculiar genetics, including the phenomenon of heteroplasmy. Most of the data on mtDNA and longevity have been obtained on humans and particularly on centenarians, i. e. , people who escaped or delayed the major age‐related pathologies and reached the extreme limit of human lifespan. In this review we summarize the most recent advances in this field that suggest a consistent role in human longevity of both germ‐line inherited and somatically acquired mutations. The particular case of the association with longevity of the somatic C150T mutation is extensively discussed, challenging the tenet that mtDNA mutations are basically detrimental. We also stress several limitations of our present knowledge, regarding the difficulty in extrapolating to humans the results obtained in animal models, owing to a variety of biological differences, including the very limited genetic variability of mtDNA in the strains used in laboratory experiments. The use of high‐throughput technologies and the extensive analysis, possibly at the single cell level, of different tissues and cell types derived from the same individual will help in disentangling the complexity of mtDNA in aging and longevity." @default.
- W1979222777 created "2016-06-24" @default.
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- W1979222777 date "2008-06-01" @default.
- W1979222777 modified "2023-09-23" @default.
- W1979222777 title "The impact of mitochondrial DNA on human lifespan: A view from studies on centenarians" @default.
- W1979222777 cites W1503357796 @default.
- W1979222777 cites W1621005218 @default.
- W1979222777 cites W1838909952 @default.
- W1979222777 cites W1879890282 @default.
- W1979222777 cites W1917926680 @default.
- W1979222777 cites W1967329313 @default.
- W1979222777 cites W1968844625 @default.
- W1979222777 cites W1968952472 @default.
- W1979222777 cites W1973930840 @default.
- W1979222777 cites W1981789085 @default.
- W1979222777 cites W1984168321 @default.
- W1979222777 cites W1992071930 @default.
- W1979222777 cites W1995706959 @default.
- W1979222777 cites W2000730064 @default.
- W1979222777 cites W2001383615 @default.
- W1979222777 cites W2005649856 @default.
- W1979222777 cites W2005758857 @default.
- W1979222777 cites W2009043082 @default.
- W1979222777 cites W2012643031 @default.
- W1979222777 cites W2014047578 @default.
- W1979222777 cites W2015116743 @default.
- W1979222777 cites W2017035597 @default.
- W1979222777 cites W2024472871 @default.
- W1979222777 cites W2027042725 @default.
- W1979222777 cites W2032097381 @default.
- W1979222777 cites W2036140173 @default.
- W1979222777 cites W2036988144 @default.
- W1979222777 cites W2039663806 @default.
- W1979222777 cites W2040303536 @default.
- W1979222777 cites W2044897807 @default.
- W1979222777 cites W2050377513 @default.
- W1979222777 cites W2053031374 @default.
- W1979222777 cites W2053222738 @default.
- W1979222777 cites W2054007006 @default.
- W1979222777 cites W2054511417 @default.
- W1979222777 cites W2055827399 @default.
- W1979222777 cites W2057645411 @default.
- W1979222777 cites W2058178327 @default.
- W1979222777 cites W2058982072 @default.
- W1979222777 cites W2063301281 @default.
- W1979222777 cites W2063728375 @default.
- W1979222777 cites W2066016132 @default.
- W1979222777 cites W2067623665 @default.
- W1979222777 cites W2072056861 @default.
- W1979222777 cites W2073851375 @default.
- W1979222777 cites W2074303856 @default.
- W1979222777 cites W2075815316 @default.
- W1979222777 cites W2079092251 @default.
- W1979222777 cites W2079414980 @default.
- W1979222777 cites W2082402714 @default.
- W1979222777 cites W2084237578 @default.
- W1979222777 cites W2084621494 @default.
- W1979222777 cites W2086005166 @default.
- W1979222777 cites W2088649670 @default.
- W1979222777 cites W2088977552 @default.
- W1979222777 cites W2094832206 @default.
- W1979222777 cites W2095915630 @default.
- W1979222777 cites W2101565524 @default.
- W1979222777 cites W2102095161 @default.
- W1979222777 cites W2102186047 @default.
- W1979222777 cites W2102507011 @default.
- W1979222777 cites W2104591129 @default.
- W1979222777 cites W2105754268 @default.
- W1979222777 cites W2110830677 @default.
- W1979222777 cites W2113350679 @default.
- W1979222777 cites W2117517043 @default.
- W1979222777 cites W2119549041 @default.
- W1979222777 cites W2119627167 @default.
- W1979222777 cites W2126327879 @default.
- W1979222777 cites W2130403475 @default.
- W1979222777 cites W2130588024 @default.
- W1979222777 cites W2132102439 @default.
- W1979222777 cites W2143462304 @default.
- W1979222777 cites W2143513584 @default.
- W1979222777 cites W2146950471 @default.
- W1979222777 cites W2149600853 @default.
- W1979222777 cites W2153029275 @default.
- W1979222777 cites W2153209823 @default.
- W1979222777 cites W2158615962 @default.
- W1979222777 cites W2164291978 @default.
- W1979222777 cites W2167241262 @default.