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• W1979226182 abstract "In voltage-clamped Xenopus oocytes injected with embryonic guinea pig mRNA, effective concentrations of extracellular ATP elicited an inward fluctuating current. This current, carried by Cl-ions, was mainly dependent upon liberation of Ca2+ ions from stores as demonstrated by experiments using intracellular EGTA loading and TMB-8 superfusion. Neomycin inhibited these fluctuating currents indicating that the transplanted purinoceptor is linked to phospholipase C activity and triggers Ins(1,4,5)P3 formation. Ins(1,4,5)P3 production evoked by external ATP was clearly demonstrated by directly measuring the water-soluble Ins(1,4,5)P3 level in injected oocytes. Finally, it is suggested that the ATP effect was mediated by a Ca2+ release from Ins(1,4,5)P3 sensitive pools since heparin blocked the ATP responsiveness. The acquired purinoceptor may be made apparent to a P2 subtype since ATP and ADP were equipotent in eliciting Cl- current while AMP and Adenosine were ineffective in injected oocytes." @default.
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• W1979226182 date "1990-12-17" @default.
• W1979226182 modified "2023-10-14" @default.
• W1979226182 title "Ins(1,4,5)P3formation and fluctuating chloride current response induced by external ATP inXenopusoocytes injected with embryonic guinea pig brain mRNA" @default.
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• W1979226182 doi "https://doi.org/10.1016/0014-5793(90)80845-a" @default.
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