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• W1979231993 abstract "Although renal functional changes in thyroid disorders may be clinically self-evident in varied patterns of water and electrolyte derangement, water retention or diuresis, the precise sites and character of the renal cellular effects of the thyroid hormone remain obscure. Indeed, the diversity of responses elicited by thyroxine (T4), triiodothyronine (T3), and their variably iodinated analogues in different species, in different tissues, or even in different portions of the same cells or subcellular organelles [1–4] makes it quite difficult at present to formulate reliable heuristic generalizations. The striking alterations in calori-genesis, oxygen consumption, growth and development, neurohumoral regulation and metabolic activity of every description cannot yet be correlated with any single fundamental molecular event. It seems fairly certain, in fact, that this complexity arises in part from an interplay of primary, secondary and still more remote reactions not easily subjected to dissociation and analysis. This is particularly the case for the kidney, where changes at the cellular level are modified and complicated by systemic hemodynamic adjustments that spring from a homeostatic need to assure excretory balance and that produce in turn still more striking departures from normal in renal function. The processes of growth, differentiation and metamorphosis introduce additional uncertainties because they are affected by thyroid dysfunction and further modify response patterns. Study of isolated tissues, cells or subcellular components may avoid these confusing difficulties but since it does so at the peril of garnering data having little relevance to the situation in life, interpretation must be hesitant and guarded." @default.
• W1979231993 created "2016-06-24" @default.
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• W1979231993 date "1974-11-01" @default.
• W1979231993 modified "2023-09-26" @default.
• W1979231993 title "The thyroid and the kidney" @default.
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• W1979231993 doi "https://doi.org/10.1038/ki.1974.119" @default.
• W1979231993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4431166" @default.
• W1979231993 hasPublicationYear "1974" @default.
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