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• W1979235320 abstract "Methotrexate was developed in 1949 as a synthetic folic acid analogue to compete with folic acid and thus interfere with cell replication. While initially developed as a potential treatment for acute lymphoblastic leukaemia, a serendipitous observation led to methotrexate's use to effect the dramatic cure of a case of advanced choriocarcinoma. This prompted the exploration for the potential of methotrexate to treat other conditions involving disordered trophoblastic tissue. Methotrexate has subsequently revolutionized the treatment of two pregnancy-related conditions-gestational trophoblastic neoplasia and ectopic pregnancy. This article reviews the development of modern treatment protocols that use methotrexate to medically treat these two important gynaecological conditions." @default.
• W1979235320 created "2016-06-24" @default.
• W1979235320 creator A5016172520 @default.
• W1979235320 creator A5044161059 @default.
• W1979235320 date "2012-02-19" @default.
• W1979235320 modified "2023-09-27" @default.
• W1979235320 title "The Evolution of Methotrexate as a Treatment for Ectopic Pregnancy and Gestational Trophoblastic Neoplasia: A Review" @default.
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• W1979235320 doi "https://doi.org/10.5402/2012/637094" @default.
• W1979235320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3302016" @default.
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