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- W1979236516 abstract "[4-14-Labelled 5α-androstane-3β,17β-diol was intravenously injected into two normal volunteer men. The urinary radioactive 17-oxo and 17β-hydroxy steroids derived from this precursor were isolated and identified by crystallization to constant specific activity. Results indicated that the major part of injected [4-14C]-5α-androstane-3β,17β-diol was converted into urinary androsterone and 5α-androstane-3α,17β-diol. This suggests that circulating 5α-androstane-3β,17β-diol was not an end metabolite. Among polar metabolites derived from [4-14C]-5α-androstane-3β,17β-diol injected in vivo, 2α- and 7α-hydroxylated metabolites were identified. If 2α-hydroxylation is probably restricted to the liver, the origin and physiological significance of 7α-hydroxylated metabolites remain to be determined." @default.
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- W1979236516 date "1981-07-01" @default.
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- W1979236516 title "In vivo metabolism of 14C-labelled 5α-androstane-3β,17β-diol" @default.
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- W1979236516 doi "https://doi.org/10.1016/0022-4731(81)90378-2" @default.
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