FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979242912> ?p ?o ?g. }

• W1979242912 endingPage "9380" @default.
• W1979242912 startingPage "9373" @default.
• W1979242912 abstract "Local statins implant has been shown to promote bone healing, the underlying mechanisms are unclear. The purpose of this study was to test the effect of local simvastatin implant on bone defect healing; to evaluate the mobilization, migration, and homing of bone marrow-derived mesenchymal stem cells (BMSCs) and endothelial progenitor cells (EPCs) induced by simvastatin. We found that local simvastatin implant increased bone formation by 51.8% (week 6) and 64.8% (week 12) compared with polyglycolic acid controls (P < 0.01), as verified by X-ray, CT, and histology. Simvastatin increased migration capacity of BMSCs and EPCs in vitro (P < 0.05). Local simvastatin implant increased mobilization of EPCs to the peripheral blood by 127% revealed by FACS analysis (P < 0.01), and increased osteogenic BMSCs to the peripheral blood dramatically revealed by Alizarin Red-S staining for mineralized nodules formation. Pre-transplanted GFP-transfected BMSCs as a tracing cell and bioluminescence imaging revealed that local simvastatin implant recruited GFP-labeled BMSC. Also, local simvastatin implant induced the HIF-1α and BMP-2 expression. In conclusion, local simvastatin implantation promotes bone defect healing, where the underlying mechanism appears to involve the higher expression of HIF-1α and BMP-2, thus recruit autogenous osteogenic and angiogenetic stem cells to the bone defect area implanted with simvastatin." @default.
• W1979242912 created "2016-06-24" @default.
• W1979242912 creator A5000196334 @default.
• W1979242912 creator A5023546935 @default.
• W1979242912 creator A5054860540 @default.
• W1979242912 creator A5055881409 @default.
• W1979242912 creator A5074876487 @default.
• W1979242912 creator A5076788877 @default.
• W1979242912 creator A5079814738 @default.
• W1979242912 creator A5083357263 @default.
• W1979242912 date "2013-12-01" @default.
• W1979242912 modified "2023-09-25" @default.
• W1979242912 title "Calvarial defect healing by recruitment of autogenous osteogenic stem cells using locally applied simvastatin" @default.
• W1979242912 cites W1666062720 @default.
• W1979242912 cites W1757602702 @default.
• W1979242912 cites W1964381756 @default.
• W1979242912 cites W1970224514 @default.
• W1979242912 cites W1973096997 @default.
• W1979242912 cites W1977175847 @default.
• W1979242912 cites W1977437881 @default.
• W1979242912 cites W1978370369 @default.
• W1979242912 cites W1986415053 @default.
• W1979242912 cites W1987575252 @default.
• W1979242912 cites W1988090351 @default.
• W1979242912 cites W1993220539 @default.
• W1979242912 cites W1995000205 @default.
• W1979242912 cites W1996446383 @default.
• W1979242912 cites W2000111747 @default.
• W1979242912 cites W2001282249 @default.
• W1979242912 cites W2001347353 @default.
• W1979242912 cites W2002925712 @default.
• W1979242912 cites W2008511671 @default.
• W1979242912 cites W2009214237 @default.
• W1979242912 cites W2014648588 @default.
• W1979242912 cites W2015639818 @default.
• W1979242912 cites W2020364703 @default.
• W1979242912 cites W2040275316 @default.
• W1979242912 cites W2041889817 @default.
• W1979242912 cites W2044490651 @default.
• W1979242912 cites W2049855386 @default.
• W1979242912 cites W2053058764 @default.
• W1979242912 cites W2056000778 @default.
• W1979242912 cites W2058143379 @default.
• W1979242912 cites W2066817161 @default.
• W1979242912 cites W2068739980 @default.
• W1979242912 cites W2073573977 @default.
• W1979242912 cites W2080789499 @default.
• W1979242912 cites W2084231836 @default.
• W1979242912 cites W2084933092 @default.
• W1979242912 cites W2091342622 @default.
• W1979242912 cites W2095384160 @default.
• W1979242912 cites W2102591328 @default.
• W1979242912 cites W2105290236 @default.
• W1979242912 cites W2107259575 @default.
• W1979242912 cites W2108287070 @default.
• W1979242912 cites W2117649842 @default.
• W1979242912 cites W2130634454 @default.
• W1979242912 cites W2137443910 @default.
• W1979242912 cites W2137629471 @default.
• W1979242912 cites W2141421900 @default.
• W1979242912 cites W2149748738 @default.
• W1979242912 cites W2163768016 @default.
• W1979242912 cites W4241333469 @default.
• W1979242912 doi "https://doi.org/10.1016/j.biomaterials.2013.08.060" @default.
• W1979242912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24016857" @default.
• W1979242912 hasPublicationYear "2013" @default.
• W1979242912 type Work @default.
• W1979242912 sameAs 1979242912 @default.
• W1979242912 citedByCount "57" @default.
• W1979242912 countsByYear W19792429122014 @default.
• W1979242912 countsByYear W19792429122015 @default.
• W1979242912 countsByYear W19792429122016 @default.
• W1979242912 countsByYear W19792429122017 @default.
• W1979242912 countsByYear W19792429122018 @default.
• W1979242912 countsByYear W19792429122019 @default.
• W1979242912 countsByYear W19792429122020 @default.
• W1979242912 countsByYear W19792429122021 @default.
• W1979242912 countsByYear W19792429122022 @default.
• W1979242912 countsByYear W19792429122023 @default.
• W1979242912 crossrefType "journal-article" @default.
• W1979242912 hasAuthorship W1979242912A5000196334 @default.
• W1979242912 hasAuthorship W1979242912A5023546935 @default.
• W1979242912 hasAuthorship W1979242912A5054860540 @default.
• W1979242912 hasAuthorship W1979242912A5055881409 @default.
• W1979242912 hasAuthorship W1979242912A5074876487 @default.
• W1979242912 hasAuthorship W1979242912A5076788877 @default.
• W1979242912 hasAuthorship W1979242912A5079814738 @default.
• W1979242912 hasAuthorship W1979242912A5083357263 @default.
• W1979242912 hasConcept C105702510 @default.
• W1979242912 hasConcept C126322002 @default.
• W1979242912 hasConcept C141071460 @default.
• W1979242912 hasConcept C142724271 @default.
• W1979242912 hasConcept C151872237 @default.
• W1979242912 hasConcept C16685009 @default.
• W1979242912 hasConcept C18903297 @default.
• W1979242912 hasConcept C198826908 @default.
• W1979242912 hasConcept C201750760 @default.
• W1979242912 hasConcept C2776329913 @default.

• next