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- W1979244807 abstract "Ca(2+) acts as global second messenger involved in the regulation of all aspects of cell function. A multitude of Ca(2+)-sensor proteins containing the specific Ca(2+) binding motif (helix-loop-helix, called EF-hand) developed early in evolution. Calmodulin (CAM) as the prototypical Ca(2+)-sensor with four EF-hands and its family members troponin-C (TNC), myosin light chains, and parvalbumin originated by gene duplications and fusions from a CAM precursor protein in prokaryotes. Rapid and precise regulation of heart and skeletal muscle contraction is assured by integration of TNC in the contractile structure and CAM in the sarcolemmal L-type Ca(2+) entry channel and in the sarcoplasmic Ca(2+) release channel RYR. The S100 proteins as evolutionary latecomers occur only in the animal subphylum vertebrates. They are not involved in switching on and off key cell functions but rather operate as modulators. In the heart S100A1 modulates Ca(2+) homeostasis, contractile inotropy, and energy production by interaction with the elements involved in these functions. The binding properties of different Ca(2+)-sensor proteins associated with specific regulatory and modulatory functions in muscle are discussed in detail. Some of these sensor proteins are critically involved in certain diseases and are now used in clinical diagnostics." @default.
- W1979244807 created "2016-06-24" @default.
- W1979244807 creator A5012494228 @default.
- W1979244807 creator A5020380292 @default.
- W1979244807 date "2008-04-01" @default.
- W1979244807 modified "2023-10-13" @default.
- W1979244807 title "Calcium, troponin, calmodulin, S100 proteins: From myocardial basics to new therapeutic strategies" @default.
- W1979244807 cites W141855200 @default.
- W1979244807 cites W1485297825 @default.
- W1979244807 cites W1495195805 @default.
- W1979244807 cites W1534230245 @default.
- W1979244807 cites W1542647594 @default.
- W1979244807 cites W1546916742 @default.
- W1979244807 cites W1550330933 @default.
- W1979244807 cites W1554417971 @default.
- W1979244807 cites W1556375320 @default.
- W1979244807 cites W1558754585 @default.
- W1979244807 cites W1567413936 @default.
- W1979244807 cites W1571243084 @default.
- W1979244807 cites W1576403707 @default.
- W1979244807 cites W1576575094 @default.
- W1979244807 cites W1579779725 @default.
- W1979244807 cites W1589645365 @default.
- W1979244807 cites W1599096372 @default.
- W1979244807 cites W1605459033 @default.
- W1979244807 cites W1662341216 @default.
- W1979244807 cites W16895699 @default.
- W1979244807 cites W175475926 @default.
- W1979244807 cites W1822457402 @default.
- W1979244807 cites W1856856507 @default.
- W1979244807 cites W1886896866 @default.
- W1979244807 cites W1939658395 @default.
- W1979244807 cites W1941910566 @default.
- W1979244807 cites W1963729113 @default.
- W1979244807 cites W1964234893 @default.
- W1979244807 cites W1965495371 @default.
- W1979244807 cites W1965661118 @default.
- W1979244807 cites W1967060390 @default.
- W1979244807 cites W1972994243 @default.
- W1979244807 cites W1976951740 @default.
- W1979244807 cites W1978088815 @default.
- W1979244807 cites W1978964592 @default.
- W1979244807 cites W1982469770 @default.
- W1979244807 cites W1986380984 @default.
- W1979244807 cites W1989644658 @default.
- W1979244807 cites W1990955455 @default.
- W1979244807 cites W1991158686 @default.
- W1979244807 cites W1996141717 @default.
- W1979244807 cites W1999296295 @default.
- W1979244807 cites W2001141072 @default.
- W1979244807 cites W2001261561 @default.
- W1979244807 cites W2001536811 @default.
- W1979244807 cites W2002621138 @default.
- W1979244807 cites W2003739799 @default.
- W1979244807 cites W2004620514 @default.
- W1979244807 cites W2008794259 @default.
- W1979244807 cites W2009293261 @default.
- W1979244807 cites W2011562987 @default.
- W1979244807 cites W2012369036 @default.
- W1979244807 cites W2013399946 @default.
- W1979244807 cites W2013496803 @default.
- W1979244807 cites W2018643387 @default.
- W1979244807 cites W2019980332 @default.
- W1979244807 cites W2022916581 @default.
- W1979244807 cites W2023591835 @default.
- W1979244807 cites W2024209352 @default.
- W1979244807 cites W2027716300 @default.
- W1979244807 cites W2028259195 @default.
- W1979244807 cites W2029625486 @default.
- W1979244807 cites W2029754434 @default.
- W1979244807 cites W2041492137 @default.
- W1979244807 cites W2044736178 @default.
- W1979244807 cites W2044992731 @default.
- W1979244807 cites W2048514487 @default.
- W1979244807 cites W2048867275 @default.
- W1979244807 cites W2049547138 @default.
- W1979244807 cites W2051567036 @default.
- W1979244807 cites W2052021933 @default.
- W1979244807 cites W2053332435 @default.
- W1979244807 cites W2057801650 @default.
- W1979244807 cites W2057976520 @default.
- W1979244807 cites W2060889917 @default.
- W1979244807 cites W2061373572 @default.
- W1979244807 cites W2061959498 @default.
- W1979244807 cites W2063685321 @default.
- W1979244807 cites W2065140692 @default.
- W1979244807 cites W2066322915 @default.
- W1979244807 cites W2066800858 @default.
- W1979244807 cites W2070742041 @default.
- W1979244807 cites W2072381529 @default.
- W1979244807 cites W2073416181 @default.
- W1979244807 cites W2074403994 @default.
- W1979244807 cites W2075947943 @default.
- W1979244807 cites W2076206378 @default.
- W1979244807 cites W2078104334 @default.
- W1979244807 cites W2078148011 @default.
- W1979244807 cites W2079571541 @default.
- W1979244807 cites W2082754501 @default.