FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979262259> ?p ?o ?g. }

• W1979262259 endingPage "1630" @default.
• W1979262259 startingPage "1625" @default.
• W1979262259 abstract "The endothelin type A (ETA) receptor was studied in six healthy subjects on two occasions with or without an ETA receptor (BQ-123) blockade. At 40 min of either BQ-123 or NaCl infusion, a concomitant infusion of the endothelin-1 (ET-1) precursor, big ET-1, was initiated to augment ET-1 formation. Blood samples were taken from catheters in a peripheral artery, the renal and femoral veins, and the pulmonary artery. Forty minutes of infusion with BQ-123 alone increased heart rate (P<0.001) and cardiac output (CO; P<0.01) and depressed mean arterial blood pressure (P<0.001) and systemic vascular resistance (SVR; P<0.01). During infusion of big ET-1 alone, CO, stroke volume, and renal blood flow decreased (P<0.01), whereas SVR and pulmonary and renal vascular resistance increased (P<0.05). These responses to big ET-1 were abolished or diminished by BQ-123. Renal ET-1 release was threefold higher when big ET-1 infusion was preceded by BQ-123 infusion (P<0.001). Arterial ET-1 concentrations rose to similar levels after big ET-1 infusion (P<0.01) in both trials because of elevated concomitant pulmonary uptake (P<0.05) after ETA blockade. Although there was no net ET-1 leg exchange, leg ET-1 turnover was higher after big ET-1 was preceded by BQ-123. Gene expression of endothelin-converting enzyme 1 and ET-1 in skeletal muscle remained unaltered on both occasions. Our data demonstrate that the level of circulating ET-1 is regulated by ETA receptor-mediated negative feedback. This mechanism seems to be coupled to increased conversion of big ET-1 and is most potent in the kidneys. This emphasizes the important physiological role of ETA receptors in the kidneys, and the lung seems to be mainly a clearing organ for ET-1." @default.
• W1979262259 created "2016-06-24" @default.
• W1979262259 creator A5024467832 @default.
• W1979262259 creator A5048551894 @default.
• W1979262259 creator A5065187178 @default.
• W1979262259 date "2010-06-01" @default.
• W1979262259 modified "2023-10-13" @default.
• W1979262259 title "The impact of the endothelin type A receptor on regional endothelin-1 turnover, in particular renal endothelin-1 release, in humans" @default.
• W1979262259 cites W1545831225 @default.
• W1979262259 cites W1977343715 @default.
• W1979262259 cites W1989425353 @default.
• W1979262259 cites W1993391283 @default.
• W1979262259 cites W1999840419 @default.
• W1979262259 cites W2000892838 @default.
• W1979262259 cites W2001252757 @default.
• W1979262259 cites W2029171451 @default.
• W1979262259 cites W2059369537 @default.
• W1979262259 cites W2074636215 @default.
• W1979262259 cites W2141253131 @default.
• W1979262259 cites W2151869895 @default.
• W1979262259 cites W2156543149 @default.
• W1979262259 cites W2159819952 @default.
• W1979262259 cites W2160974089 @default.
• W1979262259 cites W2162804111 @default.
• W1979262259 cites W2270085340 @default.
• W1979262259 cites W2283220147 @default.
• W1979262259 cites W2333322030 @default.
• W1979262259 cites W2341398312 @default.
• W1979262259 cites W2439984647 @default.
• W1979262259 cites W4206981117 @default.
• W1979262259 cites W4251140433 @default.
• W1979262259 doi "https://doi.org/10.1152/japplphysiol.00881.2009" @default.
• W1979262259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20150570" @default.
• W1979262259 hasPublicationYear "2010" @default.
• W1979262259 type Work @default.
• W1979262259 sameAs 1979262259 @default.
• W1979262259 citedByCount "3" @default.
• W1979262259 countsByYear W19792622592014 @default.
• W1979262259 countsByYear W19792622592017 @default.
• W1979262259 countsByYear W19792622592020 @default.
• W1979262259 crossrefType "journal-article" @default.
• W1979262259 hasAuthorship W1979262259A5024467832 @default.
• W1979262259 hasAuthorship W1979262259A5048551894 @default.
• W1979262259 hasAuthorship W1979262259A5065187178 @default.
• W1979262259 hasConcept C126322002 @default.
• W1979262259 hasConcept C134018914 @default.
• W1979262259 hasConcept C142225936 @default.
• W1979262259 hasConcept C144980905 @default.
• W1979262259 hasConcept C149601957 @default.
• W1979262259 hasConcept C170493617 @default.
• W1979262259 hasConcept C2780091579 @default.
• W1979262259 hasConcept C58245268 @default.
• W1979262259 hasConcept C71924100 @default.
• W1979262259 hasConcept C84393581 @default.
• W1979262259 hasConceptScore W1979262259C126322002 @default.
• W1979262259 hasConceptScore W1979262259C134018914 @default.
• W1979262259 hasConceptScore W1979262259C142225936 @default.
• W1979262259 hasConceptScore W1979262259C144980905 @default.
• W1979262259 hasConceptScore W1979262259C149601957 @default.
• W1979262259 hasConceptScore W1979262259C170493617 @default.
• W1979262259 hasConceptScore W1979262259C2780091579 @default.
• W1979262259 hasConceptScore W1979262259C58245268 @default.
• W1979262259 hasConceptScore W1979262259C71924100 @default.
• W1979262259 hasConceptScore W1979262259C84393581 @default.
• W1979262259 hasIssue "6" @default.
• W1979262259 hasLocation W19792622591 @default.
• W1979262259 hasLocation W19792622592 @default.
• W1979262259 hasOpenAccess W1979262259 @default.
• W1979262259 hasPrimaryLocation W19792622591 @default.
• W1979262259 hasRelatedWork W1968790869 @default.
• W1979262259 hasRelatedWork W1986368006 @default.
• W1979262259 hasRelatedWork W1992367101 @default.
• W1979262259 hasRelatedWork W1996866409 @default.
• W1979262259 hasRelatedWork W2006876044 @default.
• W1979262259 hasRelatedWork W2053466542 @default.
• W1979262259 hasRelatedWork W2056069181 @default.
• W1979262259 hasRelatedWork W2107168049 @default.
• W1979262259 hasRelatedWork W2377343248 @default.
• W1979262259 hasRelatedWork W3141812581 @default.
• W1979262259 hasVolume "108" @default.
• W1979262259 isParatext "false" @default.
• W1979262259 isRetracted "false" @default.
• W1979262259 magId "1979262259" @default.
• W1979262259 workType "article" @default.