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- W1979263239 abstract "BENZODIAZEPINES, a class of drugs that includes compounds such as diazepam (Valium), are frequently prescribed because of their anxiolytic, anticonvulsant, musclerelaxant, and hypnotic properties. It has been shown that the pharmacological effects of benzodiazepines are mediated via a specific receptor complex located in the central nervous system (CNS); benzodiazepines bind to a domain that allosterically regulates chloride channel gating by γ-aminobutyric acid (GABA), on GABAA receptors (1–3). In 1977, while searching for specific benzodiazepine receptors, Braestrup and Squires (4) observed the presence of high density radiolabeled diazepam binding sites in the kidney. Since then, numerous papers have reported that this class of benzodiazepine binding sites is present apparently in all tissues examined including the CNS (Section III). Because of their abundance in peripheral tissues and in order to distinguish them from the GABAA or central benzodiazepine receptors, this class of benzodiazepine binding sites was named “peripheral-type benzodiazepine-type benzodiazepine binding sites.” Moreover, in the last 5 yr several studies reported physiological roles for these binding sites and they were then termed “peripheraltype benzodiazepine receptors” (PBRs) (5–8). However, there are a number of names that have been assigned to this receptor:" @default.
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- W1979263239 date "1993-04-01" @default.
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- W1979263239 title "Peripheral-Type Benzodiazepine/Diazepam Binding Inhibitor Receptor: Biological Role in Steroidogenic Cell Function*" @default.
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- W1979263239 doi "https://doi.org/10.1210/edrv-14-2-222" @default.
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