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• W1979264516 abstract "Huntington's disease is a neurodegenerative disorder characterized by a selective degeneration of striatal projection neurons, which deal with choreic movements. Neuroprotective therapy could be achieved with the knowledge of the specific trophic requirements of these neuronal populations. Thus, the induction of endogenous trophic response or the exogenous administration of neurotrophic factors may help to prevent or stop the progression of the illness. Excitotoxicity has been implicated in the etiology of Huntington's disease, because intrastriatal injection of glutamate receptor agonists reproduces some of the neuropathological features of this disorder. Activation of glutamate receptors in the striatum differentially regulates the expression of neurotrophins, glial cell line-derived neurotrophic factor (GDNF), neurturin, and their receptors in the striatum and in its connections, cortex, and substantia nigra, showing a selective trophic response against excitotoxic insults. Transplantation of cells genetically engineered to release neurotrophic factors in the striatum has been used to study the neuroprotective effects of neurotrophin and GDNF family members in the excitotoxic model of Huntington's disease. Neurotrophins (brain-derived neurotrophic factor [BDNF], neurotrophin-3, and neurotrophin-4) protected striatal projection neurons against quinolinic or kainic acid treatment. However, GDNF family members showed a more specific action. Neurturin only protected gamma-aminobutyric acid (GABA)/enkephalinergic neurons that project to the external segment of the globus pallidus, whereas GDNF exerts its effects on GABA/substance P positive neurons, which project to the substantia nigra pars compacta and the internal segment of the globus pallidus. In conclusion, the trophic requirements of each population of striatal projection neurons are due to a complex interaction between several neurotrophic factors, such as neurotrophins and GDNF family members, which can be modified, in different pathological conditions. Moreover, these neurotrophic factors may be able to provide selective protection for basal ganglia circuits, which are affected in striatonigral degenerative disorders, such as Huntington's disease or multisystem atrophy." @default.
• W1979264516 created "2016-06-24" @default.
• W1979264516 creator A5031490806 @default.
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• W1979264516 date "2002-04-01" @default.
• W1979264516 modified "2023-10-17" @default.
• W1979264516 title "Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington’s disease" @default.
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• W1979264516 cites W1576672022 @default.
• W1979264516 cites W1578346366 @default.
• W1979264516 cites W1606173244 @default.
• W1979264516 cites W1606950487 @default.
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• W1979264516 cites W1965842668 @default.
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• W1979264516 cites W1972853510 @default.
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• W1979264516 cites W1990339051 @default.
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• W1979264516 cites W1997772243 @default.
• W1979264516 cites W1998327106 @default.
• W1979264516 cites W2002529858 @default.
• W1979264516 cites W2002741808 @default.
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• W1979264516 cites W2004652909 @default.
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• W1979264516 cites W2036426415 @default.
• W1979264516 cites W2036748407 @default.
• W1979264516 cites W2045270004 @default.
• W1979264516 cites W2047636024 @default.
• W1979264516 cites W2051455449 @default.
• W1979264516 cites W2051871118 @default.
• W1979264516 cites W2053958557 @default.
• W1979264516 cites W2057955051 @default.
• W1979264516 cites W2058176457 @default.
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• W1979264516 doi "https://doi.org/10.1016/s0361-9230(01)00775-4" @default.
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