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• W1979282021 endingPage "e69479" @default.
• W1979282021 startingPage "e69479" @default.
• W1979282021 abstract "West Nile virus (WNV) is a worldwide distributed mosquito-borne flavivirus that naturally cycles between birds and mosquitoes, although it can infect multiple vertebrate hosts including horses and humans. This virus is responsible for recurrent epidemics of febrile illness and encephalitis, and has recently become a global concern. WNV requires to transit through intracellular acidic compartments at two different steps to complete its infectious cycle. These include fusion between the viral envelope and the membrane of endosomes during viral entry, and virus maturation in the trans-Golgi network. In this study, we followed a genetic approach to study the connections between viral components and acidic pH. A WNV mutant with increased resistance to the acidotropic compound NH4Cl, which blocks organelle acidification and inhibits WNV infection, was selected. Nucleotide sequencing revealed that this mutant displayed a single amino acid substitution (Lys 3 to Glu) on the highly basic internal capsid or core (C) protein. The functional role of this replacement was confirmed by its introduction into a WNV infectious clone. This single amino acid substitution also increased resistance to other acidification inhibitor (concanamycin A) and induced a reduction of the neurovirulence in mice. Interestingly, a naturally occurring accompanying mutation found on prM protein abolished the resistant phenotype, supporting the idea of a genetic crosstalk between the internal C protein and the external glycoproteins of the virion. The findings here reported unveil a non-previously assessed connection between the C viral protein and the acidic pH necessary for entry and proper exit of flaviviruses." @default.
• W1979282021 created "2016-06-24" @default.
• W1979282021 creator A5016275952 @default.
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• W1979282021 creator A5057764651 @default.
• W1979282021 creator A5080773540 @default.
• W1979282021 creator A5083988458 @default.
• W1979282021 date "2013-07-18" @default.
• W1979282021 modified "2023-10-18" @default.
• W1979282021 title "A Single Amino Acid Substitution in the Core Protein of West Nile Virus Increases Resistance to Acidotropic Compounds" @default.
• W1979282021 cites W1566236542 @default.
• W1979282021 cites W1580917700 @default.
• W1979282021 cites W1959254653 @default.
• W1979282021 cites W1964367064 @default.
• W1979282021 cites W1966277979 @default.
• W1979282021 cites W1968071906 @default.
• W1979282021 cites W1969133921 @default.
• W1979282021 cites W1969935656 @default.
• W1979282021 cites W1978520991 @default.
• W1979282021 cites W1981726862 @default.
• W1979282021 cites W1983505024 @default.
• W1979282021 cites W1991178857 @default.
• W1979282021 cites W1995854338 @default.
• W1979282021 cites W1997632815 @default.
• W1979282021 cites W1999927176 @default.
• W1979282021 cites W2000351107 @default.
• W1979282021 cites W2002545308 @default.
• W1979282021 cites W2003328677 @default.
• W1979282021 cites W2003925822 @default.
• W1979282021 cites W2004680936 @default.
• W1979282021 cites W2005262608 @default.
• W1979282021 cites W2008216856 @default.
• W1979282021 cites W2011882057 @default.
• W1979282021 cites W2014366923 @default.
• W1979282021 cites W2018789255 @default.
• W1979282021 cites W2019186461 @default.
• W1979282021 cites W2020501709 @default.
• W1979282021 cites W2023422813 @default.
• W1979282021 cites W2030391009 @default.
• W1979282021 cites W2034231880 @default.
• W1979282021 cites W2046311880 @default.
• W1979282021 cites W2049285992 @default.
• W1979282021 cites W2051618934 @default.
• W1979282021 cites W2053820259 @default.
• W1979282021 cites W2056138506 @default.
• W1979282021 cites W2057635506 @default.
• W1979282021 cites W2058172590 @default.
• W1979282021 cites W2059687382 @default.
• W1979282021 cites W2062183101 @default.
• W1979282021 cites W2067036816 @default.
• W1979282021 cites W2070174904 @default.
• W1979282021 cites W2070721147 @default.
• W1979282021 cites W2071783064 @default.
• W1979282021 cites W2073421561 @default.
• W1979282021 cites W2076483355 @default.
• W1979282021 cites W2077035576 @default.
• W1979282021 cites W2079966062 @default.
• W1979282021 cites W2080405903 @default.
• W1979282021 cites W2080933271 @default.
• W1979282021 cites W2084926821 @default.
• W1979282021 cites W2091271343 @default.
• W1979282021 cites W2093781944 @default.
• W1979282021 cites W2095048886 @default.
• W1979282021 cites W2100878787 @default.
• W1979282021 cites W2102575242 @default.
• W1979282021 cites W2105414274 @default.
• W1979282021 cites W2105529947 @default.
• W1979282021 cites W2105973954 @default.
• W1979282021 cites W2110672706 @default.
• W1979282021 cites W2115425661 @default.
• W1979282021 cites W2116885823 @default.
• W1979282021 cites W2117484859 @default.
• W1979282021 cites W2118586702 @default.
• W1979282021 cites W2121726045 @default.
• W1979282021 cites W2123032625 @default.
• W1979282021 cites W2135550231 @default.
• W1979282021 cites W2137833977 @default.
• W1979282021 cites W2138338888 @default.
• W1979282021 cites W2140630012 @default.
• W1979282021 cites W2143086182 @default.
• W1979282021 cites W2143782963 @default.
• W1979282021 cites W2144192177 @default.
• W1979282021 cites W2144484204 @default.
• W1979282021 cites W2148538365 @default.
• W1979282021 cites W2152770371 @default.
• W1979282021 cites W2157339376 @default.
• W1979282021 cites W2158095584 @default.
• W1979282021 cites W2162607832 @default.
• W1979282021 cites W2164275111 @default.
• W1979282021 cites W2166561873 @default.
• W1979282021 cites W2167005142 @default.
• W1979282021 cites W2171529151 @default.
• W1979282021 cites W4239275885 @default.
• W1979282021 cites W4361851718 @default.
• W1979282021 doi "https://doi.org/10.1371/journal.pone.0069479" @default.
• W1979282021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3715472" @default.
• W1979282021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23874963" @default.

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