Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979291208> ?p ?o ?g. }
- W1979291208 endingPage "1666" @default.
- W1979291208 startingPage "1653" @default.
- W1979291208 abstract "The interaction between human immunodeficiency virus type 1 (HIV-1) and human T cell leukemia-lymphoma virus type I (HTLV-I) has generated substantial interest. However, there is disagreement on the in vivo consequences of the double infection. We investigated the interactions between HIV-1 and HTLV-I in monocyte-derived macrophages cultured in vitro. For study, the T cell-tropic strain IIIB and the macrophagetropic strain Ada-M of HIV-1 were used. The HTLV-I was prepared from the supernatants of the virus-producing MT-2 cell line. We found that coinfection of macrophages with T cell-tropic HIV-1 and HTLV-I significantly enhanced HIV-1 replication, whereas double infection of the cells with macrophage-tropic HIV-1 and HTLV-I resulted in marked upregulation of HTLV-I production. Stimulatory interactions between HIV-1 and HTLV-I were mediated by their trans-acting proteins. Results of study on nuclear translocation of proviral DNA showed that the tax gene product of HTLV-I was able to facilitate the nuclear import of the reverse-transcribed HIV-1(IIIB) DNA. In contrast, the HIV-1 Tat protein did not increase the intranuclear trafficking of HTLV-I DNA, which suggests another mechanism for HTLV-I enhancement by the tat gene product. In conclusion, this study provides possible mechanisms whereby coinfection of an individual with HIV-1 and HTLV-I may influence the clinical outcome of double infection." @default.
- W1979291208 created "2016-06-24" @default.
- W1979291208 creator A5001101937 @default.
- W1979291208 creator A5002085074 @default.
- W1979291208 creator A5008403618 @default.
- W1979291208 creator A5051695644 @default.
- W1979291208 creator A5053315614 @default.
- W1979291208 creator A5076380897 @default.
- W1979291208 creator A5083556564 @default.
- W1979291208 creator A5083702771 @default.
- W1979291208 creator A5090781260 @default.
- W1979291208 date "1999-12-10" @default.
- W1979291208 modified "2023-09-26" @default.
- W1979291208 title "Differential Patterns of Interaction between HIV Type 1 and HTLV Type I in Monocyte-Derived Macrophages Cultured in Vitro : Implications for in Vivo Coinfection with HIV Type 1 and HTLV Type I" @default.
- W1979291208 cites W1479877946 @default.
- W1979291208 cites W1505236901 @default.
- W1979291208 cites W1517686904 @default.
- W1979291208 cites W1539291165 @default.
- W1979291208 cites W1616413236 @default.
- W1979291208 cites W1679721892 @default.
- W1979291208 cites W1723922714 @default.
- W1979291208 cites W1794017375 @default.
- W1979291208 cites W1817018401 @default.
- W1979291208 cites W1893232111 @default.
- W1979291208 cites W1932752516 @default.
- W1979291208 cites W1934417703 @default.
- W1979291208 cites W1966425882 @default.
- W1979291208 cites W1966842441 @default.
- W1979291208 cites W1968873679 @default.
- W1979291208 cites W1970634297 @default.
- W1979291208 cites W1971290197 @default.
- W1979291208 cites W1971982144 @default.
- W1979291208 cites W1973434669 @default.
- W1979291208 cites W1975258429 @default.
- W1979291208 cites W1976302367 @default.
- W1979291208 cites W1977282539 @default.
- W1979291208 cites W1978771608 @default.
- W1979291208 cites W1984249923 @default.
- W1979291208 cites W1984836566 @default.
- W1979291208 cites W1985353241 @default.
- W1979291208 cites W1988145052 @default.
- W1979291208 cites W1989035987 @default.
- W1979291208 cites W1991670386 @default.
- W1979291208 cites W1996183144 @default.
- W1979291208 cites W1997521650 @default.
- W1979291208 cites W2001243226 @default.
- W1979291208 cites W2002601205 @default.
- W1979291208 cites W2007649868 @default.
- W1979291208 cites W2012858698 @default.
- W1979291208 cites W2015326137 @default.
- W1979291208 cites W2016534065 @default.
- W1979291208 cites W2019508559 @default.
- W1979291208 cites W2025696302 @default.
- W1979291208 cites W2026681255 @default.
- W1979291208 cites W2032026535 @default.
- W1979291208 cites W2037411475 @default.
- W1979291208 cites W2040365986 @default.
- W1979291208 cites W2042578530 @default.
- W1979291208 cites W2047385013 @default.
- W1979291208 cites W2050937329 @default.
- W1979291208 cites W2053443462 @default.
- W1979291208 cites W2054391444 @default.
- W1979291208 cites W2058350611 @default.
- W1979291208 cites W2059483648 @default.
- W1979291208 cites W2059931962 @default.
- W1979291208 cites W2065114401 @default.
- W1979291208 cites W2066121768 @default.
- W1979291208 cites W2069667541 @default.
- W1979291208 cites W2069770920 @default.
- W1979291208 cites W2070537208 @default.
- W1979291208 cites W2075147125 @default.
- W1979291208 cites W2076634735 @default.
- W1979291208 cites W2078712088 @default.
- W1979291208 cites W2078883220 @default.
- W1979291208 cites W2084415176 @default.
- W1979291208 cites W2086044183 @default.
- W1979291208 cites W2086143621 @default.
- W1979291208 cites W2086424034 @default.
- W1979291208 cites W2088493593 @default.
- W1979291208 cites W2088851522 @default.
- W1979291208 cites W2097183306 @default.
- W1979291208 cites W2098746214 @default.
- W1979291208 cites W2099002154 @default.
- W1979291208 cites W2101133789 @default.
- W1979291208 cites W2106804406 @default.
- W1979291208 cites W2107550321 @default.
- W1979291208 cites W2113282092 @default.
- W1979291208 cites W2120357172 @default.
- W1979291208 cites W2121940219 @default.
- W1979291208 cites W2132142355 @default.
- W1979291208 cites W2147351662 @default.
- W1979291208 cites W2147907754 @default.
- W1979291208 cites W2150240929 @default.
- W1979291208 cites W2153176056 @default.
- W1979291208 cites W2156657499 @default.
- W1979291208 cites W2169150485 @default.
- W1979291208 cites W2315994695 @default.
- W1979291208 doi "https://doi.org/10.1089/088922299309694" @default.