Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979306044> ?p ?o ?g. }
- W1979306044 endingPage "984" @default.
- W1979306044 startingPage "967" @default.
- W1979306044 abstract "Traumatic injury to the adult mammalian central nervous system (CNS) leads to complex cellular responses. Among them, the scar tissue formed is generally recognized as a major obstacle to CNS repair, both by the production of inhibitory molecules and by the physical impedance of axon regrowth. Therefore, scar-modulating treatments have become a leading therapeutic intervention for CNS injury. To date, a variety of biological and pharmaceutical treatments, targeting scar modulation, have been tested in animal models of CNS injury, and a few are likely to enter clinical trials. In this review, we summarize current knowledge of the scar-modulating treatments according to their specific aims: (1) inhibition of glial and fibrotic scar formation, and (2) blockade of the production of scar-associated inhibitory molecules. The removal of existing scar tissue is also discussed as a treatment of choice. It is believed that only a combinatorial strategy is likely to help eliminate the detrimental effects of scar tissue on CNS repair." @default.
- W1979306044 created "2016-06-24" @default.
- W1979306044 creator A5040205022 @default.
- W1979306044 creator A5046221264 @default.
- W1979306044 creator A5088536927 @default.
- W1979306044 date "2014-06-24" @default.
- W1979306044 modified "2023-09-24" @default.
- W1979306044 title "Scar-modulating treatments for central nervous system injury" @default.
- W1979306044 cites W1487231908 @default.
- W1979306044 cites W1535136623 @default.
- W1979306044 cites W1566509581 @default.
- W1979306044 cites W1676877312 @default.
- W1979306044 cites W1688463639 @default.
- W1979306044 cites W1718462190 @default.
- W1979306044 cites W1942474822 @default.
- W1979306044 cites W1957468634 @default.
- W1979306044 cites W1964801456 @default.
- W1979306044 cites W1964923113 @default.
- W1979306044 cites W1966778303 @default.
- W1979306044 cites W1967450020 @default.
- W1979306044 cites W1969444386 @default.
- W1979306044 cites W1969619562 @default.
- W1979306044 cites W1970901436 @default.
- W1979306044 cites W1972654114 @default.
- W1979306044 cites W1976908887 @default.
- W1979306044 cites W1977841940 @default.
- W1979306044 cites W1979228875 @default.
- W1979306044 cites W1980073515 @default.
- W1979306044 cites W1981554128 @default.
- W1979306044 cites W1983400501 @default.
- W1979306044 cites W1983712592 @default.
- W1979306044 cites W1985501522 @default.
- W1979306044 cites W1990099307 @default.
- W1979306044 cites W1990720792 @default.
- W1979306044 cites W1991890632 @default.
- W1979306044 cites W1993433521 @default.
- W1979306044 cites W1995065451 @default.
- W1979306044 cites W1995642086 @default.
- W1979306044 cites W1995886170 @default.
- W1979306044 cites W1996243257 @default.
- W1979306044 cites W1996778863 @default.
- W1979306044 cites W1997042103 @default.
- W1979306044 cites W1997403611 @default.
- W1979306044 cites W1998417937 @default.
- W1979306044 cites W2003111176 @default.
- W1979306044 cites W2003289175 @default.
- W1979306044 cites W2003326405 @default.
- W1979306044 cites W2007011517 @default.
- W1979306044 cites W2007035508 @default.
- W1979306044 cites W2009086604 @default.
- W1979306044 cites W2011874786 @default.
- W1979306044 cites W2012846191 @default.
- W1979306044 cites W2012974800 @default.
- W1979306044 cites W2013997823 @default.
- W1979306044 cites W2015827697 @default.
- W1979306044 cites W2015952490 @default.
- W1979306044 cites W2016011604 @default.
- W1979306044 cites W2019038565 @default.
- W1979306044 cites W2019610319 @default.
- W1979306044 cites W2020850411 @default.
- W1979306044 cites W2021318239 @default.
- W1979306044 cites W2023034837 @default.
- W1979306044 cites W2023371306 @default.
- W1979306044 cites W2024317850 @default.
- W1979306044 cites W2025778924 @default.
- W1979306044 cites W2027536371 @default.
- W1979306044 cites W2028641015 @default.
- W1979306044 cites W2028772339 @default.
- W1979306044 cites W2030028290 @default.
- W1979306044 cites W2035616055 @default.
- W1979306044 cites W2036587607 @default.
- W1979306044 cites W2036771184 @default.
- W1979306044 cites W2038594557 @default.
- W1979306044 cites W2040578112 @default.
- W1979306044 cites W2043245400 @default.
- W1979306044 cites W2043930451 @default.
- W1979306044 cites W2045369881 @default.
- W1979306044 cites W2047787703 @default.
- W1979306044 cites W2047958993 @default.
- W1979306044 cites W2050057735 @default.
- W1979306044 cites W2052248831 @default.
- W1979306044 cites W2053103428 @default.
- W1979306044 cites W2057767129 @default.
- W1979306044 cites W2058116209 @default.
- W1979306044 cites W2061095488 @default.
- W1979306044 cites W2061354480 @default.
- W1979306044 cites W2062994751 @default.
- W1979306044 cites W2063468575 @default.
- W1979306044 cites W2065752935 @default.
- W1979306044 cites W2067673651 @default.
- W1979306044 cites W2069172906 @default.
- W1979306044 cites W2069825753 @default.
- W1979306044 cites W2071663291 @default.
- W1979306044 cites W2072334074 @default.
- W1979306044 cites W2072821348 @default.
- W1979306044 cites W2073394261 @default.
- W1979306044 cites W2073493529 @default.
- W1979306044 cites W2073804293 @default.