Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979312912> ?p ?o ?g. }
- W1979312912 endingPage "523" @default.
- W1979312912 startingPage "512" @default.
- W1979312912 abstract "Cytochrome P-450 LM4 (RH, reduced flavoprotein:oxygen oxidoreductase (RH-hydroxylating), EC 1.14.14.1) from rabbit liver microsomes was chemically modified with tetranitromethane. Nitration of two tyrosine residues inhibits the p-nitrophenetole O-deethylase activity of the enzyme by about 80%. Sequencing the 3-nitrotyrosine-containing peptides after HPLC tryptic peptide mapping reveals that mainly Tyr-243 and Tyr-271 are nitrated, whereas Tyr-71, Tyr-188 and Tyr-365 are modified to a lower extent. Nitration of tyrosine residues affects the complex formation with p-nitrophenetole, α-naphthoflavone and metyrapone as indicated by an increased affinity towards p-nitrophenetole and by a decreased affinity for the latter compounds. Furthermore, nitration interferes with the electron transfer from NADPH-cytochrome P-450-reductase to cytochrome P-450 LM4 resulting in a slowed down reduction reaction. The results suggest that Tyr-243 and Tyr-271 of cytochrome P-450 LM4 are functionally involved in the interaction with NADPH-cytochrome P-450 reductase." @default.
- W1979312912 created "2016-06-24" @default.
- W1979312912 creator A5024740581 @default.
- W1979312912 creator A5038907851 @default.
- W1979312912 creator A5046637013 @default.
- W1979312912 creator A5056540780 @default.
- W1979312912 creator A5087930915 @default.
- W1979312912 creator A5088604488 @default.
- W1979312912 date "1987-12-01" @default.
- W1979312912 modified "2023-09-23" @default.
- W1979312912 title "Chemical modification of cytochrome P-450 LM4. Identification of functionally linked tyrosine residues" @default.
- W1979312912 cites W1234052980 @default.
- W1979312912 cites W1441295830 @default.
- W1979312912 cites W1483640295 @default.
- W1979312912 cites W1513874533 @default.
- W1979312912 cites W1517877140 @default.
- W1979312912 cites W1566398256 @default.
- W1979312912 cites W1582535572 @default.
- W1979312912 cites W1582769766 @default.
- W1979312912 cites W1588794217 @default.
- W1979312912 cites W168751598 @default.
- W1979312912 cites W1847131948 @default.
- W1979312912 cites W1884649498 @default.
- W1979312912 cites W1981708194 @default.
- W1979312912 cites W1986196653 @default.
- W1979312912 cites W1987345891 @default.
- W1979312912 cites W1990987413 @default.
- W1979312912 cites W1993561299 @default.
- W1979312912 cites W1996933563 @default.
- W1979312912 cites W1997037941 @default.
- W1979312912 cites W2006370393 @default.
- W1979312912 cites W2022309078 @default.
- W1979312912 cites W2028258535 @default.
- W1979312912 cites W2038244727 @default.
- W1979312912 cites W2065139041 @default.
- W1979312912 cites W2067252410 @default.
- W1979312912 cites W2072291087 @default.
- W1979312912 cites W2076166680 @default.
- W1979312912 cites W2085800992 @default.
- W1979312912 cites W2090002733 @default.
- W1979312912 cites W2095566173 @default.
- W1979312912 cites W2319936908 @default.
- W1979312912 cites W4302566315 @default.
- W1979312912 cites W967021459 @default.
- W1979312912 doi "https://doi.org/10.1016/0167-4838(87)90198-1" @default.
- W1979312912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3120780" @default.
- W1979312912 hasPublicationYear "1987" @default.
- W1979312912 type Work @default.
- W1979312912 sameAs 1979312912 @default.
- W1979312912 citedByCount "24" @default.
- W1979312912 countsByYear W19793129122012 @default.
- W1979312912 countsByYear W19793129122015 @default.
- W1979312912 countsByYear W19793129122019 @default.
- W1979312912 crossrefType "journal-article" @default.
- W1979312912 hasAuthorship W1979312912A5024740581 @default.
- W1979312912 hasAuthorship W1979312912A5038907851 @default.
- W1979312912 hasAuthorship W1979312912A5046637013 @default.
- W1979312912 hasAuthorship W1979312912A5056540780 @default.
- W1979312912 hasAuthorship W1979312912A5087930915 @default.
- W1979312912 hasAuthorship W1979312912A5088604488 @default.
- W1979312912 hasConcept C134651460 @default.
- W1979312912 hasConcept C178790620 @default.
- W1979312912 hasConcept C181199279 @default.
- W1979312912 hasConcept C185592680 @default.
- W1979312912 hasConcept C2775856698 @default.
- W1979312912 hasConcept C2776165026 @default.
- W1979312912 hasConcept C2777337673 @default.
- W1979312912 hasConcept C2777622882 @default.
- W1979312912 hasConcept C2779268744 @default.
- W1979312912 hasConcept C2779385521 @default.
- W1979312912 hasConcept C2780768313 @default.
- W1979312912 hasConcept C2781109383 @default.
- W1979312912 hasConcept C526171541 @default.
- W1979312912 hasConcept C55493867 @default.
- W1979312912 hasConcept C71240020 @default.
- W1979312912 hasConcept C87644729 @default.
- W1979312912 hasConceptScore W1979312912C134651460 @default.
- W1979312912 hasConceptScore W1979312912C178790620 @default.
- W1979312912 hasConceptScore W1979312912C181199279 @default.
- W1979312912 hasConceptScore W1979312912C185592680 @default.
- W1979312912 hasConceptScore W1979312912C2775856698 @default.
- W1979312912 hasConceptScore W1979312912C2776165026 @default.
- W1979312912 hasConceptScore W1979312912C2777337673 @default.
- W1979312912 hasConceptScore W1979312912C2777622882 @default.
- W1979312912 hasConceptScore W1979312912C2779268744 @default.
- W1979312912 hasConceptScore W1979312912C2779385521 @default.
- W1979312912 hasConceptScore W1979312912C2780768313 @default.
- W1979312912 hasConceptScore W1979312912C2781109383 @default.
- W1979312912 hasConceptScore W1979312912C526171541 @default.
- W1979312912 hasConceptScore W1979312912C55493867 @default.
- W1979312912 hasConceptScore W1979312912C71240020 @default.
- W1979312912 hasConceptScore W1979312912C87644729 @default.
- W1979312912 hasIssue "3" @default.
- W1979312912 hasLocation W19793129121 @default.
- W1979312912 hasLocation W19793129122 @default.
- W1979312912 hasOpenAccess W1979312912 @default.
- W1979312912 hasPrimaryLocation W19793129121 @default.
- W1979312912 hasRelatedWork W1519761244 @default.