FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979319954> ?p ?o ?g. }

• W1979319954 endingPage "226" @default.
• W1979319954 startingPage "220" @default.
• W1979319954 abstract "Epidermal growth factor receptor (EGFR) is produced during the molecular pathogenesis of glioma, and new anti-EGFR molecules are available for therapeutics. Consequently, analyses of the EGFR gene and protein are frequently used for glioma characterization. We compare the accuracy and the usefulness of 2 currently used techniques for histologic classification of gliomas. Fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) techniques were used to assess EGFR gene amplification and protein abundance in a series of 35 gliomas, including World Health Organization (WHO) grade I, II, and III astrocytomas (AI, AII, AIII), grade II and III tumors with oligodendroglial component (OII, OIII) and grade IV glioblastomas (GBs). EGFR gene amplification was found in one-third of the tumors studied. It was frequent in GB and OIII but was never found in AI, AII, AIII, and OII tumors. IHC and FISH provided similar findings for grade of tumor, despite the fact that, in contrast to the FISH gene amplification, EGFR protein was overexpressed in AIII and in GB. EGFR gene amplification was never observed in tumors not containing EGFR protein: therefore FISH is unnecessary when IHC shows no EGFR protein expression. EGFR gene amplification seems to be restricted to high-grade tumors, WHO grade IV astrocytomas, and grade III oligodendroglial tumors." @default.
• W1979319954 created "2016-06-24" @default.
• W1979319954 creator A5006187873 @default.
• W1979319954 creator A5010371806 @default.
• W1979319954 creator A5010808146 @default.
• W1979319954 creator A5013111728 @default.
• W1979319954 creator A5023155543 @default.
• W1979319954 creator A5024839155 @default.
• W1979319954 creator A5025020900 @default.
• W1979319954 creator A5029876930 @default.
• W1979319954 creator A5052003746 @default.
• W1979319954 creator A5065943601 @default.
• W1979319954 creator A5067675413 @default.
• W1979319954 date "2009-05-01" @default.
• W1979319954 modified "2023-10-13" @default.
• W1979319954 title "Determination of EGFR Status in Gliomas" @default.
• W1979319954 cites W1978177843 @default.
• W1979319954 cites W1984741306 @default.
• W1979319954 cites W1988442083 @default.
• W1979319954 cites W2009785997 @default.
• W1979319954 cites W2020888615 @default.
• W1979319954 cites W2044470367 @default.
• W1979319954 cites W2044930054 @default.
• W1979319954 cites W2058197551 @default.
• W1979319954 cites W2058836795 @default.
• W1979319954 cites W2063867686 @default.
• W1979319954 cites W2064047613 @default.
• W1979319954 cites W2068347405 @default.
• W1979319954 cites W2077632702 @default.
• W1979319954 cites W2078419463 @default.
• W1979319954 cites W2087276802 @default.
• W1979319954 cites W2111710483 @default.
• W1979319954 cites W2117521607 @default.
• W1979319954 cites W2122885616 @default.
• W1979319954 cites W2123099415 @default.
• W1979319954 cites W2126372889 @default.
• W1979319954 cites W2126523653 @default.
• W1979319954 cites W2130743783 @default.
• W1979319954 cites W2138604360 @default.
• W1979319954 cites W2148930326 @default.
• W1979319954 cites W2151794458 @default.
• W1979319954 cites W2154670277 @default.
• W1979319954 cites W2157824687 @default.
• W1979319954 cites W2160382843 @default.
• W1979319954 cites W2164572775 @default.
• W1979319954 cites W2317801714 @default.
• W1979319954 cites W4235412254 @default.
• W1979319954 cites W54894650 @default.
• W1979319954 doi "https://doi.org/10.1097/pai.0b013e31818db320" @default.
• W1979319954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19391220" @default.
• W1979319954 hasPublicationYear "2009" @default.
• W1979319954 type Work @default.
• W1979319954 sameAs 1979319954 @default.
• W1979319954 citedByCount "22" @default.
• W1979319954 countsByYear W19793199542012 @default.
• W1979319954 countsByYear W19793199542013 @default.
• W1979319954 countsByYear W19793199542015 @default.
• W1979319954 countsByYear W19793199542016 @default.
• W1979319954 countsByYear W19793199542017 @default.
• W1979319954 countsByYear W19793199542022 @default.
• W1979319954 countsByYear W19793199542023 @default.
• W1979319954 crossrefType "journal-article" @default.
• W1979319954 hasAuthorship W1979319954A5006187873 @default.
• W1979319954 hasAuthorship W1979319954A5010371806 @default.
• W1979319954 hasAuthorship W1979319954A5010808146 @default.
• W1979319954 hasAuthorship W1979319954A5013111728 @default.
• W1979319954 hasAuthorship W1979319954A5023155543 @default.
• W1979319954 hasAuthorship W1979319954A5024839155 @default.
• W1979319954 hasAuthorship W1979319954A5025020900 @default.
• W1979319954 hasAuthorship W1979319954A5029876930 @default.
• W1979319954 hasAuthorship W1979319954A5052003746 @default.
• W1979319954 hasAuthorship W1979319954A5065943601 @default.
• W1979319954 hasAuthorship W1979319954A5067675413 @default.
• W1979319954 hasConcept C104317684 @default.
• W1979319954 hasConcept C126322002 @default.
• W1979319954 hasConcept C142724271 @default.
• W1979319954 hasConcept C170493617 @default.
• W1979319954 hasConcept C204232928 @default.
• W1979319954 hasConcept C2777542201 @default.
• W1979319954 hasConcept C2778227246 @default.
• W1979319954 hasConcept C2779438470 @default.
• W1979319954 hasConcept C2909208804 @default.
• W1979319954 hasConcept C30481170 @default.
• W1979319954 hasConcept C502942594 @default.
• W1979319954 hasConcept C505870484 @default.
• W1979319954 hasConcept C54355233 @default.
• W1979319954 hasConcept C71924100 @default.
• W1979319954 hasConcept C7602840 @default.
• W1979319954 hasConcept C86803240 @default.
• W1979319954 hasConceptScore W1979319954C104317684 @default.
• W1979319954 hasConceptScore W1979319954C126322002 @default.
• W1979319954 hasConceptScore W1979319954C142724271 @default.
• W1979319954 hasConceptScore W1979319954C170493617 @default.
• W1979319954 hasConceptScore W1979319954C204232928 @default.
• W1979319954 hasConceptScore W1979319954C2777542201 @default.
• W1979319954 hasConceptScore W1979319954C2778227246 @default.
• W1979319954 hasConceptScore W1979319954C2779438470 @default.
• W1979319954 hasConceptScore W1979319954C2909208804 @default.

• next