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- W1979331393 abstract "The 14-3-3 proteins constitute a family of conserved proteins present in all eukaryotic organisms so far investigated. These proteins have attracted interest because they are involved in important cellular processes such as signal transduction, cell-cycle control, apoptosis, stress response and malignant transformation and because at least 100 different binding partners for the 14-3-3 proteins have been reported. Although the exact function of 14-3-3 proteins is still unknown, they are known to (1) act as adaptor molecules stimulating protein-protein interactions, (2) regulate the subcellular localisation of proteins and (3) activate or inhibit enzymes. In this review, we discuss the role of the 14-3-3 proteins in three cellular processes: cell cycle control, signal transduction and apoptosis. These processes are regulated by the 14-3-3 proteins at multiple steps. The 14-3-3 proteins have an overall inhibitory effect on cell cycle progression and apoptosis, whereas in signal transduction they may act as stimulatory or inhibitory factors. This article contains supplementary material which may be viewed at the BioEssays website at http://www.interscience.wiley.com/jpages/0265-9247/Suppmat/23/v23_10.936." @default.
- W1979331393 created "2016-06-24" @default.
- W1979331393 creator A5010372182 @default.
- W1979331393 creator A5078257437 @default.
- W1979331393 creator A5080041059 @default.
- W1979331393 date "2001-10-01" @default.
- W1979331393 modified "2023-09-26" @default.
- W1979331393 title "14-3-3 proteins: key regulators of cell division, signalling and apoptosis" @default.
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- W1979331393 doi "https://doi.org/10.1002/bies.1134" @default.
- W1979331393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11598960" @default.
- W1979331393 hasPublicationYear "2001" @default.
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