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- W1979333896 abstract "An intraventricular injection of a potent GABAB receptor antagonist, 2-hydroxysaclofen, elicited luteinizing hormone (LH) secretion in a dose-dependent manner under the negative feedback condition in ovariectomized estrogen-primed rats. Significant reduction of the effect of 2-hydroxysaclofen by baclofen, a selective GABAB agonist, suggested that the antagonist stimulated LH secretion through interaction with the GABAB receptor. These results provide evidence that the endogenous GABA acting at the GABAB receptor plays a physiological role in controlling basal LH secretion." @default.
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- W1979333896 date "1991-04-01" @default.
- W1979333896 modified "2023-09-25" @default.
- W1979333896 title "2-Hydroxysaclofen, a potent GABAB receptor antagonist, stimulates luteinizing hormone secretion in female rats" @default.
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- W1979333896 doi "https://doi.org/10.1016/0006-8993(91)91169-2" @default.
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