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- W1979343721 abstract "Pretreatment of white or black rats with desmethylimipramine prevented the fall in brain noradrenaline content induced by intraventricular 6-hydroxydopamine but did not prevent the reduction in Y-maze exploratory behaviour or conditioned avoidance response behaviour. In black rats desmethylimipramine pretreatment did not prevent the fall in brain dopamine content induced by 6-hydroxydopamine. Pretreatment with both d- and l-amphetamine prevented or reduced the depletion of brain dopamine content by 6-hydroxydopamine and also prevented or reduced the inhibition of conditioned avoidance behaviour. These results suggest that the effects of 6-hydroxydopamine on conditioned avoidance response behaviour are mediated through dopaminergic neurones; however, the behavioural effects of 6-hydroxydopamine are of relatively short duration and so do not appear to be associated with the permanent destruction of catecholamine neurones." @default.
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- W1979343721 date "1972-01-01" @default.
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- W1979343721 title "The effects of drugs on the behavioural and biochemical actions of intraventricular 6-hydroxydopamine" @default.
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- W1979343721 doi "https://doi.org/10.1016/0014-2999(72)90263-4" @default.
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