Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979347145> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1979347145 endingPage "S51" @default.
- W1979347145 startingPage "S51" @default.
- W1979347145 abstract "Acute musculoskeletal spasm and pain is a leading cause of physician visits and disability in people under 45 years of age. This community-based study compared therapeutic outcomes obtained when patients with acute musculoskeletal spasm and pain of the back or neck were treated with cyclobenzaprine 5 mg tid (Cyc5)(Flexeril®) alone or in combination with ibuprofen 400 mg tid (Cyc5/Ibu400) or ibuprofen 800 mg tid (Cyc5/Ibu800). A prospective, randomized, open-label, multi-center, 7-day study was conducted to compare Cyc5, Cyc5/Ibu400, and Cyc5/Ibu800 in patients 18–65 years of age with acute muscle spasm of the back and/or neck. Patient Global Impression of Change (PGIC; 0=worsening to 4=marked improvement) was the primary endpoint. The mean Oswestry Disability Index (ODI; calculated from the 10 section scores and normalized to 100) served as a secondary endpoint. Data were collected via an Interactive Voice Recognition System after 3 and 7 days of therapy. Patients (N=867) completing up to 7 days of therapy were assessed. The mean PGIC scores showed improvements after Day 3 (Cyc5=2.5, Cyc5/Ibu400=2.6, and Cyc5/Ibu800=2.6) and Day 7 (Cyc5=3.0, Cyc5/Ibu400=3.0, and Cyc5/Ibu800=2.9) that were comparable for each treatment group. Improvements from baseline in the mean ODI scores were also similar for each treatment group. Mean PGIC and ODI scores showed significantly (p<0.001) greater improvements after 7 days than after 3 days for all three treatments, but there were no significant differences in these scores among the 3 treatment groups on either day. The comparable improvements in PGIC and ODI observed for patients treated with Cyc5 either alone or in combination with ibuprofen (400 or 800 mg) suggest that there may be no additional benefits of taking ibuprofen if muscle relaxant therapy with Cyc5 is used for spasm and pain of the back and neck. Funded by McNeil Consumer & Specialty Pharmaceuticals." @default.
- W1979347145 created "2016-06-24" @default.
- W1979347145 creator A5007222032 @default.
- W1979347145 creator A5021286381 @default.
- W1979347145 creator A5022665362 @default.
- W1979347145 creator A5056574151 @default.
- W1979347145 creator A5061038184 @default.
- W1979347145 creator A5070873264 @default.
- W1979347145 date "2005-03-01" @default.
- W1979347145 modified "2023-09-26" @default.
- W1979347145 title "Cyclobenzaprine 5 mg versus cyclobenzaprine 5 mg plus ibuprofen for spasm and pain of the back and neck" @default.
- W1979347145 doi "https://doi.org/10.1016/j.jpain.2005.01.201" @default.
- W1979347145 hasPublicationYear "2005" @default.
- W1979347145 type Work @default.
- W1979347145 sameAs 1979347145 @default.
- W1979347145 citedByCount "0" @default.
- W1979347145 crossrefType "journal-article" @default.
- W1979347145 hasAuthorship W1979347145A5007222032 @default.
- W1979347145 hasAuthorship W1979347145A5021286381 @default.
- W1979347145 hasAuthorship W1979347145A5022665362 @default.
- W1979347145 hasAuthorship W1979347145A5056574151 @default.
- W1979347145 hasAuthorship W1979347145A5061038184 @default.
- W1979347145 hasAuthorship W1979347145A5070873264 @default.
- W1979347145 hasBestOaLocation W19793471451 @default.
- W1979347145 hasConcept C141071460 @default.
- W1979347145 hasConcept C142724271 @default.
- W1979347145 hasConcept C168563851 @default.
- W1979347145 hasConcept C1862650 @default.
- W1979347145 hasConcept C203092338 @default.
- W1979347145 hasConcept C204787440 @default.
- W1979347145 hasConcept C2775998654 @default.
- W1979347145 hasConcept C2779944601 @default.
- W1979347145 hasConcept C2780907711 @default.
- W1979347145 hasConcept C2781038967 @default.
- W1979347145 hasConcept C2910429734 @default.
- W1979347145 hasConcept C42219234 @default.
- W1979347145 hasConcept C71924100 @default.
- W1979347145 hasConcept C98274493 @default.
- W1979347145 hasConceptScore W1979347145C141071460 @default.
- W1979347145 hasConceptScore W1979347145C142724271 @default.
- W1979347145 hasConceptScore W1979347145C168563851 @default.
- W1979347145 hasConceptScore W1979347145C1862650 @default.
- W1979347145 hasConceptScore W1979347145C203092338 @default.
- W1979347145 hasConceptScore W1979347145C204787440 @default.
- W1979347145 hasConceptScore W1979347145C2775998654 @default.
- W1979347145 hasConceptScore W1979347145C2779944601 @default.
- W1979347145 hasConceptScore W1979347145C2780907711 @default.
- W1979347145 hasConceptScore W1979347145C2781038967 @default.
- W1979347145 hasConceptScore W1979347145C2910429734 @default.
- W1979347145 hasConceptScore W1979347145C42219234 @default.
- W1979347145 hasConceptScore W1979347145C71924100 @default.
- W1979347145 hasConceptScore W1979347145C98274493 @default.
- W1979347145 hasIssue "3" @default.
- W1979347145 hasLocation W19793471451 @default.
- W1979347145 hasOpenAccess W1979347145 @default.
- W1979347145 hasPrimaryLocation W19793471451 @default.
- W1979347145 hasRelatedWork W2061918260 @default.
- W1979347145 hasRelatedWork W2739358509 @default.
- W1979347145 hasRelatedWork W2763611055 @default.
- W1979347145 hasRelatedWork W2801507658 @default.
- W1979347145 hasRelatedWork W3008419941 @default.
- W1979347145 hasRelatedWork W3119135035 @default.
- W1979347145 hasRelatedWork W3179461033 @default.
- W1979347145 hasRelatedWork W4287436702 @default.
- W1979347145 hasRelatedWork W4297235546 @default.
- W1979347145 hasRelatedWork W1957155383 @default.
- W1979347145 hasVolume "6" @default.
- W1979347145 isParatext "false" @default.
- W1979347145 isRetracted "false" @default.
- W1979347145 magId "1979347145" @default.
- W1979347145 workType "article" @default.