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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979354924> ?p ?o ?g. }

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• W1979354924 abstract "The beta-cell is one of four major types of cells present in the islets of Langerhans, which are islands of cells distributed throughout the endocrine pancreas in most mammals. The beta-cell synthesizes and secretes the hormone insulin mainly in response to glucose but also in response to several nutrients, hormones and nervous stimuli. In adult rodents the beta-cell has a slow mitotic rate. Recent studies provide novel insights into the functions of the beta-cell. The presence of functional insulin-like growth factor-1 and insulin receptors and components of their signaling pathway indicate an important role for insulin/IGF-1 signaling in the regulation of beta-cell function. Further, the recent discovery of glucokinase (GK) and the ATP-dependent potassium channels on insulin secretory granules, the detection of AMP-protein kinase in the beta-cell and the identification of a new beta-cell transcription factor, mMafA, are some exciting new areas of research currently underway to further understand the complex pathways that regulate the functions of beta-cells." @default.
• W1979354924 created "2016-06-24" @default.
• W1979354924 creator A5042315373 @default.
• W1979354924 date "2004-03-01" @default.
• W1979354924 modified "2023-10-08" @default.
• W1979354924 title "The islet β-cell" @default.
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• W1979354924 doi "https://doi.org/10.1016/j.biocel.2003.08.010" @default.
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