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- W1979359195 abstract "Toll-like receptors (TLRs) are innate pathogen recognition molecules for microbial products. Lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria, is one of the most potent microbial products. LPS is recognized by TLR4 and MD-2. TLR4 is a transmembrane protein, the extracellular domain of which is composed of a protein motif called leucine-rich repeats (LRR). MD-2 is an extracellular molecule that is associated with the extracellular LRR of TLR4. MD-2 has a role in cell surface expression of TLR4 and interaction with LPS. TLR4-MD-2 contributes to containment of infections by Gram-negative bacteria by activating immune responses." @default.
- W1979359195 created "2016-06-24" @default.
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- W1979359195 date "2004-02-01" @default.
- W1979359195 modified "2023-10-17" @default.
- W1979359195 title "Endotoxin recognition molecules, Toll-like receptor 4-MD-2" @default.
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- W1979359195 doi "https://doi.org/10.1016/j.smim.2003.10.007" @default.
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