FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979359675> ?p ?o ?g. }

• W1979359675 endingPage "11" @default.
• W1979359675 startingPage "6" @default.
• W1979359675 abstract "The aim was to study the differences in the effectiveness of two types of endothelin (ET) receptor antagonists (selective ET-A or dual ET-A/B antagonists) on the hearts of streptozotocin (STZ)-induced diabetic rats (type I diabetes) at functional and biochemical/molecular levels.Citrate saline (vehicle) or STZ was injected into rats. The ET-A/B dual receptor antagonist (SB209670, 1mg/kg/day) and the ET-A receptor antagonist (TA-0201, 1mg/kg/day) were then administered to these rats. One week after injection, the animals were separated into those receiving SB209670, TA-0201 or vehicle by 4-week osmotic mini-pump.The VEGF level and percent fractional shortening in the diabetic heart were significantly decreased compared to the non-diabetic heart, whereas SB209670 and TA-0201 treatments greatly and comparably prevented this decrease. SB209670 treatment was more effective in reversing decreased expressions of KDR and phosphorylated AKT, downstream of VEGF angiogenic signaling, than TA-0201 treatment. The eNOS levels in hearts were significantly higher in diabetic rats than in healthy rats, and this increase was significantly reduced by TA-0210 but not by SB209670 treatment.Improvement of KDR mRNA and pAKT levels by SB209670 but not TA-0201 suggests that dual ET-A/-B blockade may be effective in improving intracellular systems of these components in the diabetic rat heart. However, the present study also showed that TA-0201 or SB209670 improved percent fractional shortening and VEGF levels of the diabetic hearts to a similar extent, suggesting that ET-A blockade and dual ET-A/-B blockade are similarly effective in improving cardiac dysfunction in the diabetic rats." @default.
• W1979359675 created "2016-06-24" @default.
• W1979359675 creator A5001190899 @default.
• W1979359675 creator A5002583020 @default.
• W1979359675 creator A5011572159 @default.
• W1979359675 creator A5023669115 @default.
• W1979359675 creator A5047033376 @default.
• W1979359675 creator A5047490560 @default.
• W1979359675 creator A5048935550 @default.
• W1979359675 creator A5052073274 @default.
• W1979359675 creator A5055426703 @default.
• W1979359675 creator A5064914823 @default.
• W1979359675 creator A5067111837 @default.
• W1979359675 creator A5071591384 @default.
• W1979359675 creator A5078388970 @default.
• W1979359675 creator A5089076259 @default.
• W1979359675 date "2014-08-01" @default.
• W1979359675 modified "2023-10-13" @default.
• W1979359675 title "Effects of selective endothelin (ET)-A receptor antagonist versus dual ET-A/B receptor antagonist on hearts of streptozotocin-treated diabetic rats" @default.
• W1979359675 cites W1964424550 @default.
• W1979359675 cites W1966559329 @default.
• W1979359675 cites W1973262582 @default.
• W1979359675 cites W1974310563 @default.
• W1979359675 cites W1978814735 @default.
• W1979359675 cites W1979460197 @default.
• W1979359675 cites W2015983038 @default.
• W1979359675 cites W2016879477 @default.
• W1979359675 cites W2028793163 @default.
• W1979359675 cites W2050517931 @default.
• W1979359675 cites W2053948123 @default.
• W1979359675 cites W2056551448 @default.
• W1979359675 cites W2060407689 @default.
• W1979359675 cites W2061032825 @default.
• W1979359675 cites W2074248400 @default.
• W1979359675 cites W2075075037 @default.
• W1979359675 cites W2079988400 @default.
• W1979359675 cites W2087221897 @default.
• W1979359675 cites W2093009387 @default.
• W1979359675 cites W2108668031 @default.
• W1979359675 cites W2119538739 @default.
• W1979359675 cites W2129144866 @default.
• W1979359675 cites W2135583425 @default.
• W1979359675 cites W2141046053 @default.
• W1979359675 cites W2145670548 @default.
• W1979359675 cites W2158497159 @default.
• W1979359675 cites W2160257210 @default.
• W1979359675 cites W2166362110 @default.
• W1979359675 cites W2166985430 @default.
• W1979359675 cites W2168438265 @default.
• W1979359675 cites W2417448419 @default.
• W1979359675 doi "https://doi.org/10.1016/j.lfs.2014.06.008" @default.
• W1979359675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24953608" @default.
• W1979359675 hasPublicationYear "2014" @default.
• W1979359675 type Work @default.
• W1979359675 sameAs 1979359675 @default.
• W1979359675 citedByCount "10" @default.
• W1979359675 countsByYear W19793596752015 @default.
• W1979359675 countsByYear W19793596752017 @default.
• W1979359675 countsByYear W19793596752018 @default.
• W1979359675 countsByYear W19793596752019 @default.
• W1979359675 countsByYear W19793596752021 @default.
• W1979359675 countsByYear W19793596752022 @default.
• W1979359675 crossrefType "journal-article" @default.
• W1979359675 hasAuthorship W1979359675A5001190899 @default.
• W1979359675 hasAuthorship W1979359675A5002583020 @default.
• W1979359675 hasAuthorship W1979359675A5011572159 @default.
• W1979359675 hasAuthorship W1979359675A5023669115 @default.
• W1979359675 hasAuthorship W1979359675A5047033376 @default.
• W1979359675 hasAuthorship W1979359675A5047490560 @default.
• W1979359675 hasAuthorship W1979359675A5048935550 @default.
• W1979359675 hasAuthorship W1979359675A5052073274 @default.
• W1979359675 hasAuthorship W1979359675A5055426703 @default.
• W1979359675 hasAuthorship W1979359675A5064914823 @default.
• W1979359675 hasAuthorship W1979359675A5067111837 @default.
• W1979359675 hasAuthorship W1979359675A5071591384 @default.
• W1979359675 hasAuthorship W1979359675A5078388970 @default.
• W1979359675 hasAuthorship W1979359675A5089076259 @default.
• W1979359675 hasConcept C126322002 @default.
• W1979359675 hasConcept C134018914 @default.
• W1979359675 hasConcept C144980905 @default.
• W1979359675 hasConcept C170493617 @default.
• W1979359675 hasConcept C2776345702 @default.
• W1979359675 hasConcept C2776885963 @default.
• W1979359675 hasConcept C2777622882 @default.
• W1979359675 hasConcept C2778122271 @default.
• W1979359675 hasConcept C2778326061 @default.
• W1979359675 hasConcept C2779280383 @default.
• W1979359675 hasConcept C519581460 @default.
• W1979359675 hasConcept C555293320 @default.
• W1979359675 hasConcept C71924100 @default.
• W1979359675 hasConcept C98274493 @default.
• W1979359675 hasConceptScore W1979359675C126322002 @default.
• W1979359675 hasConceptScore W1979359675C134018914 @default.
• W1979359675 hasConceptScore W1979359675C144980905 @default.
• W1979359675 hasConceptScore W1979359675C170493617 @default.
• W1979359675 hasConceptScore W1979359675C2776345702 @default.
• W1979359675 hasConceptScore W1979359675C2776885963 @default.
• W1979359675 hasConceptScore W1979359675C2777622882 @default.

• next