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- W1979359888 abstract "A mixture of 1,2-dimethyl-4-(p-carboxyphenylazo)-5-hydroxybenzene (CPA) and 1,2-dichloro-4-benzenesulfonamido-5-nitrobenzene (DCBN), when fed to white mice of the SPFS strain bearing spontaneous mammary cancers, cured permanently about one-third of the animals. In others, transient cures were observed, but the cancers eventually returned. The maximal number of cures was obtained with 6 g CPA and 0·5 g DCBN per kg of ration. Additional amounts did not increase the percentage of cures. A related compound, 1,2-dimethyl-4,5-bis(benzenesulfonamido)benzene (DMDB), also cured some cancers but seemed less potent than the combination of CPA and DCBN. Some other relatives were apparently inactive. In C3H mice, bearing spontaneous mammary cancers, CPA plus DCBN caused transient regressions of the neoplasms but did not result in permanent cures. Several substances such as aminopterin, 5-fluororacil and 5-fluorodeoxycytidine, which inhibit the growth of certain transplanted cancers of mice, did not exert any detectable effect on these spontaneous cancers. The effective compounds were conceived on the basis of the demonstration that the spontaneous cancers differed from normal host tissues in that they synthesized vitamin B12. The new compounds are members of a series of antimetabolites which have been shown to inhibit the biosynthesis of this vitamin in microorganims. However, there was no direct proof that the effect on the cancers was the result of the relationship to vitamin B12 synthesis. The compounds exerted no detectable harmful effects on the host mice at the doses used to bring about cure of the cancers. This selective toxicity was predicted from knowledge of the relationship of the analogs to the biosynthesis of vitamin B12 and riboflavin." @default.
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- W1979359888 date "1962-12-01" @default.
- W1979359888 modified "2023-09-24" @default.
- W1979359888 title "Permanent cure of some spontaneous mammary cancers of mice with analogs of 1,2-dimethyl-4,5-diaminobenzene" @default.
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- W1979359888 doi "https://doi.org/10.1016/0006-2952(62)90195-8" @default.
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