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• W1979364057 abstract "To investigate the toxicity of beta-amyloid protein which consisted of senile plaques of Alzheimer's disease (AD), this was infused into cerebral ventricle for 14 days by using mini-osmotic pump. The performance of the water maze task in beta-amyloid protein-treated rats was impaired. Choline acetyltransferase activity significantly decreased in the frontal cortex and hippocampus. These results suggest that the deposition of beta-amyloid protein in the brain is related to the impairment of learning and cholinergic neuronal degeneration, and that beta-amyloid protein-treated rats could be used as an animal model for AD." @default.
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• W1979364057 date "1994-03-01" @default.
• W1979364057 modified "2023-09-24" @default.
• W1979364057 title "β-Amyloid protein-induced Alzheimer's disease animal model" @default.
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• W1979364057 doi "https://doi.org/10.1016/0304-3940(94)90239-9" @default.
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