FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979366917> ?p ?o ?g. }

• W1979366917 endingPage "46" @default.
• W1979366917 startingPage "43" @default.
• W1979366917 abstract "We have shown previously that angiotensin‐II (A‐II) controls proto‐oncogene (c‐ fos, jun ‐B and c‐ jun ) mRNA accumulation in bovine adrenal fasciculata cells (BAC). Since BAC contain both subtypes (AT‐1 and AT‐2) of the A‐II receptor, we have investigated which subtype was involved in the effect of A‐II on proto‐oncogene mRNA by using a selective antagonist for AT‐1 (DUP 753) and for AT‐2 (CGP 42112A). DUP 753, but not CGP 421 12A, inhibited the stimulatory effect of A‐II on proto‐oncogene mRNA, with ID 3d s of 4 × 10 −7 M, 7 × 10 −7 M and 2 × 10 −6 M for c‐ fos, jun ‐B and c‐ jun , respectively. Neither of the two antagonists by themselves had a direct effect on proto‐oncogene mRNA. As the A‐II AT‐1 receptors are coupled to the phospholipase C system in BAC, we have investigated whether the A‐II effects on the proto‐oncogenes were mediated by protein kinase C (PKC) or by Ca 2+ calmodulin. First, activation of PKC by the phorbol ester, PMA, increased the level of the three proto‐oncogene mRNAs, whereas calcium ionophore had no effect. Second, staurosporine, a specific inhibitor of PKC, reduced the stimulatory action of A‐II on proto‐oncogene mRNA by 80–90%, whereas trifluoroperazine, an inhibitor of calmodulin, had no significant effect. These results demonstrate that the effects of A‐II on proto‐oncogene mRNA are mediated by AT1 receptor subtypes, mainly through activation of the PKC pathway." @default.
• W1979366917 created "2016-06-24" @default.
• W1979366917 creator A5008181234 @default.
• W1979366917 creator A5014896478 @default.
• W1979366917 creator A5064500654 @default.
• W1979366917 creator A5082177855 @default.
• W1979366917 date "1992-11-16" @default.
• W1979366917 modified "2023-10-14" @default.
• W1979366917 title "Angiotensin-II-induced expression of proto-oncogene (c-<i>fos</i>,<i>jun</i>-B and c-<i>jun</i>) mRNA in bovine adrenocortical fasciculata cells (BAC) is mediated by AT-1 receptors" @default.
• W1979366917 cites W1563230397 @default.
• W1979366917 cites W1589866689 @default.
• W1979366917 cites W1967561584 @default.
• W1979366917 cites W1968874083 @default.
• W1979366917 cites W1970388701 @default.
• W1979366917 cites W1974350281 @default.
• W1979366917 cites W1984361597 @default.
• W1979366917 cites W1998279906 @default.
• W1979366917 cites W2020734297 @default.
• W1979366917 cites W2037023622 @default.
• W1979366917 cites W2053941648 @default.
• W1979366917 cites W2057875911 @default.
• W1979366917 cites W2081924363 @default.
• W1979366917 cites W2090188464 @default.
• W1979366917 cites W2092171289 @default.
• W1979366917 cites W2105601594 @default.
• W1979366917 cites W2125701765 @default.
• W1979366917 cites W4241409035 @default.
• W1979366917 doi "https://doi.org/10.1016/0014-5793(92)81180-t" @default.
• W1979366917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1426267" @default.
• W1979366917 hasPublicationYear "1992" @default.
• W1979366917 type Work @default.
• W1979366917 sameAs 1979366917 @default.
• W1979366917 citedByCount "17" @default.
• W1979366917 crossrefType "journal-article" @default.
• W1979366917 hasAuthorship W1979366917A5008181234 @default.
• W1979366917 hasAuthorship W1979366917A5014896478 @default.
• W1979366917 hasAuthorship W1979366917A5064500654 @default.
• W1979366917 hasAuthorship W1979366917A5082177855 @default.
• W1979366917 hasBestOaLocation W19793669171 @default.
• W1979366917 hasConcept C104317684 @default.
• W1979366917 hasConcept C105580179 @default.
• W1979366917 hasConcept C153911025 @default.
• W1979366917 hasConcept C170493617 @default.
• W1979366917 hasConcept C184235292 @default.
• W1979366917 hasConcept C185592680 @default.
• W1979366917 hasConcept C195794163 @default.
• W1979366917 hasConcept C2778597717 @default.
• W1979366917 hasConcept C2779084600 @default.
• W1979366917 hasConcept C2780043322 @default.
• W1979366917 hasConcept C2781018059 @default.
• W1979366917 hasConcept C2908929049 @default.
• W1979366917 hasConcept C29537977 @default.
• W1979366917 hasConcept C55493867 @default.
• W1979366917 hasConcept C86803240 @default.
• W1979366917 hasConcept C95444343 @default.
• W1979366917 hasConceptScore W1979366917C104317684 @default.
• W1979366917 hasConceptScore W1979366917C105580179 @default.
• W1979366917 hasConceptScore W1979366917C153911025 @default.
• W1979366917 hasConceptScore W1979366917C170493617 @default.
• W1979366917 hasConceptScore W1979366917C184235292 @default.
• W1979366917 hasConceptScore W1979366917C185592680 @default.
• W1979366917 hasConceptScore W1979366917C195794163 @default.
• W1979366917 hasConceptScore W1979366917C2778597717 @default.
• W1979366917 hasConceptScore W1979366917C2779084600 @default.
• W1979366917 hasConceptScore W1979366917C2780043322 @default.
• W1979366917 hasConceptScore W1979366917C2781018059 @default.
• W1979366917 hasConceptScore W1979366917C2908929049 @default.
• W1979366917 hasConceptScore W1979366917C29537977 @default.
• W1979366917 hasConceptScore W1979366917C55493867 @default.
• W1979366917 hasConceptScore W1979366917C86803240 @default.
• W1979366917 hasConceptScore W1979366917C95444343 @default.
• W1979366917 hasIssue "1" @default.
• W1979366917 hasLocation W19793669171 @default.
• W1979366917 hasLocation W19793669172 @default.
• W1979366917 hasOpenAccess W1979366917 @default.
• W1979366917 hasPrimaryLocation W19793669171 @default.
• W1979366917 hasRelatedWork W1973153969 @default.
• W1979366917 hasRelatedWork W1999189606 @default.
• W1979366917 hasRelatedWork W2002676856 @default.
• W1979366917 hasRelatedWork W2037451652 @default.
• W1979366917 hasRelatedWork W2088454871 @default.
• W1979366917 hasRelatedWork W2108097827 @default.
• W1979366917 hasRelatedWork W2141542099 @default.
• W1979366917 hasRelatedWork W2163875176 @default.
• W1979366917 hasRelatedWork W226109780 @default.
• W1979366917 hasRelatedWork W2399430502 @default.
• W1979366917 hasVolume "313" @default.
• W1979366917 isParatext "false" @default.
• W1979366917 isRetracted "false" @default.
• W1979366917 magId "1979366917" @default.
• W1979366917 workType "article" @default.