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- W1979376435 abstract "Embolization microsphere loaded with irinotecan improve patient survival vs systemic FOLFIRI in liver metastases (Aliberti CIRSE 2011). In a model of VX2 liver metastases, we verified that the efficacy was due to irinotecan and not to the embolic and that two types of microspheres with different elution kinetics show different antitumor effects. VX2 cell suspension was injected in portal vein of 21 rabbits. After 14-21 days, multiple tumor nodules had developed in all liver lobes and embolization of common hepatic artery was performed with a fixed suspension volume of 1) bland Hepasphere 2) 100mg irinotecan-loaded HepaSphere 30/60µm, 3) 100mg irinotecan-loaded DC Bead 70-150µm. Five non-treated animals served as Control. Histology was performed at D3. Liver tumor burden was significantly reduced in IRI treated group (5% total liver surface in HS-IRI, 17% in DC-IRI) compared to Control (32%, p=0.011). The reduction was not statistically significant for Bland HS (17%, p=0.175). Tumor necrosis was significantly increased for both HS-IRI (70% total tumor surface, p=0.006) and DC-IRI (50%, p=0.047) vs Control (24%), while it did not increased significantly with Bland (22%, p=0.465). HS-IRI were more frequently located outside tumor nodules (89%) than Bland HS (69%) and DC-IRI (52%). Necrosis of normal liver parenchyma was very limited (1% liver surface), NS between the four groups (p=0.760). Irinotecan-loaded microspheres reduced tumor burden and caused significant necrosis of tumor nodules. This outcome was only due to irinotecan local delivery. The higher efficacy of HS-IRI vs DC-IRI may result from different elution kinetics or bead repartition in tumor/liver." @default.
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- W1979376435 date "2014-03-01" @default.
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- W1979376435 title "Excellent response of VX2 liver metastases to iri delivered from 2 types of microspheres" @default.
- W1979376435 doi "https://doi.org/10.1016/j.jvir.2013.12.391" @default.
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