Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979385180> ?p ?o ?g. }
- W1979385180 endingPage "149" @default.
- W1979385180 startingPage "142" @default.
- W1979385180 abstract "Mast cells are among the first cells of our immune system to encounter exogenous danger. Intracellular receptors such as nucleotide-binding oligomerization domain (Nod) play an important role in responding to invading pathogens. Here, we have investigated the response of human mast cells to the Nod1 ligand M-TriDAP. Human cord blood-derived mast cells (CBMCs) were activated with M-TriDAP alone, or in combination with the Toll-like receptor (TLR) ligands lipopolysaccharide (LPS) and zymosan. Release of pro-inflammatory chemokines and cytokines was measured by ELISA, cytometric bead array and LUMINEX, and degranulation was evaluated by analysis of histamine release. M-TriDAP induced a dose-dependent release of IL-8, MIP-1α, MIP-1β and TNF. In contrast, degranulation could not be observed. When cells were treated with M-TriDAP in combination with the TLR4 agonist LPS, but not with TLR2 agonist zymosan, the secretion of cytokines was augmented. We here present results demonstrating that human CBMCs are stimulated by the Nod1 agonist M-TriDAP alone and in combination with LPS to produce pro-inflammatory cytokines and chemokines. Our results add to the concept that mast cells constitute an important part of our host defense, as they are equipped with several types of important pattern recognition receptors, including TLRs and Nod." @default.
- W1979385180 created "2016-06-24" @default.
- W1979385180 creator A5016859188 @default.
- W1979385180 creator A5024296200 @default.
- W1979385180 creator A5034402404 @default.
- W1979385180 creator A5036630518 @default.
- W1979385180 creator A5058675648 @default.
- W1979385180 date "2010-11-24" @default.
- W1979385180 modified "2023-10-16" @default.
- W1979385180 title "Human Cord Blood-Derived Mast Cells Are Activated by the Nod1 Agonist M-TriDAP to Release Pro-Inflammatory Cytokines and Chemokines" @default.
- W1979385180 cites W1791079802 @default.
- W1979385180 cites W1833006606 @default.
- W1979385180 cites W1964822664 @default.
- W1979385180 cites W1969734421 @default.
- W1979385180 cites W1970527727 @default.
- W1979385180 cites W1974631626 @default.
- W1979385180 cites W1976217791 @default.
- W1979385180 cites W1979304701 @default.
- W1979385180 cites W1980168760 @default.
- W1979385180 cites W1995744610 @default.
- W1979385180 cites W2003634035 @default.
- W1979385180 cites W2006004907 @default.
- W1979385180 cites W2006595984 @default.
- W1979385180 cites W2008474281 @default.
- W1979385180 cites W2009364588 @default.
- W1979385180 cites W2034203371 @default.
- W1979385180 cites W2038143978 @default.
- W1979385180 cites W2040853949 @default.
- W1979385180 cites W2042433863 @default.
- W1979385180 cites W2042810511 @default.
- W1979385180 cites W2048000602 @default.
- W1979385180 cites W2050601356 @default.
- W1979385180 cites W2054614656 @default.
- W1979385180 cites W2055444322 @default.
- W1979385180 cites W2056879548 @default.
- W1979385180 cites W2059867407 @default.
- W1979385180 cites W2061443292 @default.
- W1979385180 cites W2079357488 @default.
- W1979385180 cites W2081019830 @default.
- W1979385180 cites W2081166085 @default.
- W1979385180 cites W2086923184 @default.
- W1979385180 cites W2092967353 @default.
- W1979385180 cites W2093612942 @default.
- W1979385180 cites W2095111536 @default.
- W1979385180 cites W2097082261 @default.
- W1979385180 cites W2104744330 @default.
- W1979385180 cites W2111241532 @default.
- W1979385180 cites W2112930450 @default.
- W1979385180 cites W2114159981 @default.
- W1979385180 cites W2123087827 @default.
- W1979385180 cites W2127842048 @default.
- W1979385180 cites W2136212808 @default.
- W1979385180 cites W2136736147 @default.
- W1979385180 cites W2150594596 @default.
- W1979385180 cites W2150771431 @default.
- W1979385180 doi "https://doi.org/10.1159/000321933" @default.
- W1979385180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21099203" @default.
- W1979385180 hasPublicationYear "2010" @default.
- W1979385180 type Work @default.
- W1979385180 sameAs 1979385180 @default.
- W1979385180 citedByCount "46" @default.
- W1979385180 countsByYear W19793851802012 @default.
- W1979385180 countsByYear W19793851802013 @default.
- W1979385180 countsByYear W19793851802014 @default.
- W1979385180 countsByYear W19793851802015 @default.
- W1979385180 countsByYear W19793851802016 @default.
- W1979385180 countsByYear W19793851802017 @default.
- W1979385180 countsByYear W19793851802018 @default.
- W1979385180 countsByYear W19793851802019 @default.
- W1979385180 countsByYear W19793851802020 @default.
- W1979385180 countsByYear W19793851802021 @default.
- W1979385180 countsByYear W19793851802022 @default.
- W1979385180 countsByYear W19793851802023 @default.
- W1979385180 crossrefType "journal-article" @default.
- W1979385180 hasAuthorship W1979385180A5016859188 @default.
- W1979385180 hasAuthorship W1979385180A5024296200 @default.
- W1979385180 hasAuthorship W1979385180A5034402404 @default.
- W1979385180 hasAuthorship W1979385180A5036630518 @default.
- W1979385180 hasAuthorship W1979385180A5058675648 @default.
- W1979385180 hasBestOaLocation W19793851801 @default.
- W1979385180 hasConcept C13373296 @default.
- W1979385180 hasConcept C136449434 @default.
- W1979385180 hasConcept C164027704 @default.
- W1979385180 hasConcept C170493617 @default.
- W1979385180 hasConcept C185592680 @default.
- W1979385180 hasConcept C202751555 @default.
- W1979385180 hasConcept C203014093 @default.
- W1979385180 hasConcept C2776070231 @default.
- W1979385180 hasConcept C2776914184 @default.
- W1979385180 hasConcept C2778690821 @default.
- W1979385180 hasConcept C2778870864 @default.
- W1979385180 hasConcept C2778938600 @default.
- W1979385180 hasConcept C2781236682 @default.
- W1979385180 hasConcept C49802076 @default.
- W1979385180 hasConcept C55493867 @default.
- W1979385180 hasConcept C86803240 @default.
- W1979385180 hasConcept C8891405 @default.
- W1979385180 hasConcept C95444343 @default.