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- W1979393695 abstract "More than a century ago, Armand Trousseau first described an association between cancer and the coagulation system [1,2]. Later it was discovered that tumor cells release procoagulant microvesicles (often referred to as microparticles) into the culture medium that may be responsible for activation of the coagulation system [3]. The procoagulant protein tissue factor (TF) is expressed by a variety of tumors. Importantly, levels of TF expression increase with advanced cancer stage and high levels are associated with an increased mortality [4–7]. In glioblastoma cells, TF expression is induced by hypoxia and activation of the epidermal growth factor receptor [8,9]. One reason for the increased mortality may be that cancer patients have a high rate of venous thromboembolism. For instance, 11.1% of brain cancer patients have a thrombotic event within 1 year of diagnosis [10]. Indeed, tumor cells release TF-positive microparticles into the blood in mouse models and in cancer patients, and these microparticles may be responsible for triggering venous thrombosis [11–14]. Activation of coagulation by tumor cell TF also enhances pulmonary metastasis in a fibrin-dependent manner [15,16]. Finally, tumor cell TF enhances tumor growth and angiogenesis [6,17]. An earlier study found that overexpression of TF in Meth-A sarcoma cells increased tumor growth and angiogenesis in mice [18]. More recently, Rak and colleagues [19] showed that a selective decrease in TF expression reduced the growth of human colorectal cancer cells and angiogenesis in severe combined immunodeficiency mice." @default.
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- W1979393695 date "2009-11-01" @default.
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- W1979393695 title "Tumors, ticks and tissue factor" @default.
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- W1979393695 doi "https://doi.org/10.1111/j.1538-7836.2009.03592.x" @default.
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